Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains

Keyphrases

• JAK3 100%
• Kinase Domain 100%
• Naturally Occurring mutations 100%
• Pseudokinase Domain 100%
• Complexation Effect 100%
• Kinase Activity 30%
• Phosphorylation 20%
• Severe Combined Immunodeficiency 20%
• Catalytic Activity 20%
• Catalytic Domain 20%
• Protein Expression 10%
• Janus Kinase 1 (JAK1) 10%
• B Cells 10%
• Immunocompromised Patients 10%
• Disease Pathogenesis 10%
• Tyrosine Kinase 10%
• Co-immunoprecipitation (co-IP) 10%
• Autophosphorylation 10%
• Reconstitution 10%
• Epstein-Barr Virus 10%
• In Vitro Activity 10%
• Mutant Forms 10%
• COS-7 Cells 10%
• Two-component Domains 10%
• Intramolecular Interactions 10%
• Patient-derived 10%

Immunology and Microbiology

• Pseudokinase 100%
• Kinase 100%
• Phosphotransferase 100%
• Enzyme Active Site 20%
• Severe Combined Immunodeficiency 20%
• phosphorylation 20%
• Cytokine 10%
• Wild Type 10%
• B Cell 10%
• Protein Expression 10%
• Autophosphorylation 10%
• Epstein Barr Virus 10%
• Tyrosine 10%
• In Vitro 10%