Completion of Gamma Knife radiosurgery for AVM treatment after unplanned interruption—technical note

Hari S. Raman, Lakshmi Santanam, Ananth K. Vellimana, Robert E. Drzymala, Christina I. Tsien, Gregory J. Zipfel

Research output: Contribution to journalArticlepeer-review


Background and importance Gamma Knife radiosurgery is an established technique for non-urgent treatment of various intracranial pathologies. Intra-procedural dislodgement of the stereotactic frame is an uncommon occurrence that could lead to abortion of ongoing treatment and necessitate more invasive treatment strategies. Clinical presentation In this case report, we describe a novel method for resumption of Gamma Knife treatment after an unplanned intra-procedural interruption. The case example involves a radiosurgical treatment of a Spetzler-Martin grade I arteriovenous malformation. Conclusion Our technique involves integration of scans and coordinate systems from two imaging sessions using the composite isodose line to resolve translational differences, thereby limiting delivery of remaining shots to the untreated region of the lesion. MRI follow-up at 13 months showed a reduction in the nidus size with no evidence of any radiation injury to the surrounding brain parenchyma. We believe this technique will allow care teams to effectively salvage interrupted Gamma Knife procedures and reduce progression to more invasive treatment options.

Original languageEnglish (US)
Pages (from-to)1343-1347
Number of pages5
JournalActa Neurochirurgica
Issue number12
StatePublished - Dec 2018
Externally publishedYes


  • AVM
  • Frame dislodgement
  • Gamma Knife
  • Radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Completion of Gamma Knife radiosurgery for AVM treatment after unplanned interruption—technical note'. Together they form a unique fingerprint.

Cite this