Complete spotaneous regression of pulmonary metastatic melanoma

Timothy S. Wang, Lori Lowe, John W. Smith, Isaac R. Francis, Vernon K. Sondak, Lynn Dworzanian, Steven Finkelstein, Craig L. Slingluff, Timothy M. Johnson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


BACKGROUND. Complete spontaneous regression of melanoma metastatic to the lungs is a rare event. OBJECTIVE. To report a case of biopsy-proven melanoma metastic to the lung with complete spontaneous regression. METHODS. Multidisciplinary case report. RESULTS. A 35-year-old white female was diagnosed with metastic melanoma to the lung. A pleural biopsy confirmed the diagnosis. Partial spontaneous regression was noted by a staging computed tomography scan prior to enrollment in an investigational protocol. Complete spontaneous regression occured over 5 months withtout any form of conventional or alternative therapy, and the patient remains disease-free 3 years diagnosis. CONCLUSIONS. Our case represents the seventh case of complete spontaneous regression of melanoma metastatic to the lung, and the only case with histologic confirmation of both the primary and pulmonary metastatic lesions. The patient was pregnant twice between the time of her initial diagnosis of primary melanoma and pulmonary metastatic disease.

Original languageEnglish (US)
Pages (from-to)915-919
Number of pages5
JournalDermatologic Surgery
Issue number8
StatePublished - Aug 1998
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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