Abstract
Congenital mesoblastic nephroma (CMN) is usually cured by surgery. The sensitivity of this tumor to chemotherapy is unknown. The recent description of a t(12;15)(p13;q25) chromosomal translocation in both cellular CMN and congenital infantile fibrosarcoma suggests that these entities have a common pathogenesis, and that cellular CMN might respond to chemotherapy like congenital infantile fibrosarcoma does. The authors describe three patients with recurrent cellular CMN who showed a complete response to chemotherapy. Based on these patients and a review of the literature, the authors suggest that chemotherapy be considered as a part of the therapy for recurrent or unresectable cellular CMN.
Original language | English (US) |
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Pages (from-to) | 478-481 |
Number of pages | 4 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - Aug 2002 |
Keywords
- Cancer recurrence
- Chemotherapy
- Congenital infantile fibrosarcoma
- Mesoblastic nephroma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology