Complement receptors regulate lipopolysaccharide-induced T-cell stimulation

Ziya Kaya; Theresa Tretter; Jens Schlichting; Florian Leuschner; Marina Afanasyeva; Hugo A. Katus; Noel R. Rose

doi:10.1111/j.1365-2567.2004.02113.x

Complement receptors regulate lipopolysaccharide-induced T-cell stimulation

Ziya Kaya, Theresa Tretter, Jens Schlichting, Florian Leuschner, Marina Afanasyeva, Hugo A. Katus, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44^high and CD62L^low T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4⁺ and CD8⁺ subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr^+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr^-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.

Original language	English (US)
Pages (from-to)	493-498
Number of pages	6
Journal	Immunology
Volume	114
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2567.2004.02113.x
State	Published - Apr 2005
Externally published	Yes

Keywords

Cell surface molecules
Cellular activation
Complement
Lipopolysaccharide
T lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/j.1365-2567.2004.02113.x

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title = "Complement receptors regulate lipopolysaccharide-induced T-cell stimulation",

abstract = "Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44high and CD62Llow T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4+ and CD8+ subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.",

keywords = "Cell surface molecules, Cellular activation, Complement, Lipopolysaccharide, T lymphocytes",

author = "Ziya Kaya and Theresa Tretter and Jens Schlichting and Florian Leuschner and Marina Afanasyeva and Katus, {Hugo A.} and Rose, {Noel R.}",

year = "2005",

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doi = "10.1111/j.1365-2567.2004.02113.x",

language = "English (US)",

volume = "114",

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T1 - Complement receptors regulate lipopolysaccharide-induced T-cell stimulation

AU - Kaya, Ziya

AU - Tretter, Theresa

AU - Schlichting, Jens

AU - Leuschner, Florian

AU - Afanasyeva, Marina

AU - Katus, Hugo A.

AU - Rose, Noel R.

PY - 2005/4

Y1 - 2005/4

N2 - Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44high and CD62Llow T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4+ and CD8+ subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.

AB - Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44high and CD62Llow T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4+ and CD8+ subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.

KW - Cell surface molecules

KW - Cellular activation

KW - Complement

KW - Lipopolysaccharide

KW - T lymphocytes

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ER -

Complement receptors regulate lipopolysaccharide-induced T-cell stimulation

Abstract

Keywords

ASJC Scopus subject areas

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