Compatibility testing problems associated with bovine thrombintreated plasma

Rosetta Sue Shirey, Ana B. Ciappi, Thomas S. Kickler, Darrell Triulzi, Paul M. Ness

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombinassociated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.

Original languageEnglish (US)
Pages (from-to)19-21
Number of pages3
Issue number1
StatePublished - Mar 1993

ASJC Scopus subject areas

  • General Medicine


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