Comparison of two regimens of feeding and oral electrolyte solutions in infants with diarrhea

Julius G. Goepp, Scott Katz, Elizabeth Cuervo, Raymond Reid, J. Roberto Moran, Mathuram Santosham

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Glucose-based oral rehydration solutions (ORS) available in the United States do not appear to reduce the severity or duration of diarrhea. The use of cereal-derived ORS and cereal-based feedings appears to diminish the severity of illness in studies conducted in the developing world. To our knowledge, no controlled trials of cereal-derived ORS or cereal-based feedings have been performed in the United States. Methods: We performed a randomized, double-blind trial of two ORS feeding regimens in outpatients with diarrhea. Patients aged 2-13 months with acute watery diarrhea were enrolled. Subjects received standard glucose-based ORS in alternation with soy-based, lactose-free infant formula (Group 1) or rice syrup solid containing ORS in alternation with rice-based, lactose-free infant formula (Group 2). Subjects were visited at home daily to determine the severity of illness and characteristics of the stool. Results: After the first 2 days, significantly more Group 1 subjects continued to have diarrhea than did Group 2 subjects (median duration of diarrhea 3 vs. 2 days) as demonstrated by Kaplan-Meier survival curves (p = 0.04). Conclusion: We conclude that infants fed a regimen consisting of rice syrup solid containing ORS and rice formula resolved their diarrhea sooner than did infants fed a regimen of standard glucose-based ORS with soy formula. The relative contributions of ORS and formula to this more rapid recovery can be elucidated by further studies.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Issue number4
StatePublished - Apr 1997


  • Cereal
  • Dehydration
  • Diarrhea
  • Oral rehydration solutions
  • Rehydration

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology


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