Comparison of two concentrations of amphotericin B bladder irrigation in the treatment of funguria in patients with indwelling urinary catheters

Suzanne A. Nesbit, Lynn E. Katz, Brian W. McClain, Dale P. Murphy

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of amphotericin B bladder irrigation at two concentrations was studied. Patients with funguria (≥15,000 colony-forming units of yeast per milliliter of urine), an indwelling urinary catheter, and a physician order for amphotericin B continuous bladder irrigation were randomly assigned to receive 10 or 50 mg of amphotericin B per liter of sterile water as a continuous irrigation for 72 hours at the rate of 42 mL/hr. Before the bladder irrigation began, the indwelling catheter was changed to a three-way catheter. Repeat urine cultures were performed 24 hours after the irrigation was discontinued. A total of 28 patients were enrolled from November 1993 to May 1995. The rate of eradication of the infection was 100% in the 50-mg/L group and 67% in the 10-mg/L group. Subject enrollment was stopped prematurely because all the treatment failures occurred in the 10-mg/L group. Dose was the only variable significantly associated with outcome. Bladder irrigation with amphotericin B was more effective when the drug concentration was 50 mg/L rather than 10 mg/L.

Original languageEnglish (US)
Pages (from-to)872-875
Number of pages4
JournalAmerican Journal of Health-System Pharmacy
Volume56
Issue number9
DOIs
StatePublished - May 1 1999
Externally publishedYes

Keywords

  • Amphotericin B
  • Antifungals
  • Dosage
  • Mycoses

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy

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