Abstract
Compliance with tuberculosis preventive therapy in a randomized placebo-controlled trial in 2736 HIV-infected Ugandans was measured using urinary isoniazid metabolite testing, clinic attendance, and self-report. Overall, 77% of urine tests were positive, subjects kept 85% of their scheduled visits while on therapy, and 69% reportedly never forgot to take their medication. Different strategies were used for constructing three composite compliance indices in active arms: (1) an unweighted index of the summed scores on scaled compliance measures; (2) a weighted index using weights obtained from a survey of experts on tuberculosis; and (3) a statistically weighted index using principal components analysis. Composite indices were evaluated for reliability, validity, and practical utility. Understanding of the regimen, study arm, subsequent follow-up, tuberculosis status, and urine spot-check result were associated with composite compliance scores. The unweighted index in this study performed as well as the weighted indices.
Original language | English (US) |
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Pages (from-to) | 597-607 |
Number of pages | 11 |
Journal | Journal of Clinical Epidemiology |
Volume | 51 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1998 |
Externally published | Yes |
Keywords
- Compliance
- HIV infection
- Isoniazid
- Preventive therapy
- Tuberculosis
ASJC Scopus subject areas
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Epidemiology