Comparison of Thermospray and Fast Atom Bombardment Mass Spectrometry as Solution-Dependent Ionization Techniques

Catherine Fenselau; D. J. Liberato; J. A. Yergey; R. J. Cotter; A. L. Yergey

doi:10.1021/ac00278a030

Comparison of Thermospray and Fast Atom Bombardment Mass Spectrometry as Solution-Dependent Ionization Techniques

Catherine Fenselau, D. J. Liberato, J. A. Yergey, R. J. Cotter, A. L. Yergey

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The effects of sample volatility, proton affinity, and charge on the mass spectra produced by the fast atom bombardment and thermospray Ionization techniques are compared. In general, the thermospray technique produced comparatively more fragmentation, while the dependence on sample proton affinity In the presence of ammonium acetate buffer Is similar In both techniques. Doubly charged Ions are more often formed in thermospray and may reflect differences In the Ion formation mechanisms.

Original language	English (US)
Pages (from-to)	2759-2762
Number of pages	4
Journal	Analytical Chemistry
Volume	56
Issue number	14
DOIs	https://doi.org/10.1021/ac00278a030
State	Published - Dec 1984

ASJC Scopus subject areas

Analytical Chemistry

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abstract = "The effects of sample volatility, proton affinity, and charge on the mass spectra produced by the fast atom bombardment and thermospray Ionization techniques are compared. In general, the thermospray technique produced comparatively more fragmentation, while the dependence on sample proton affinity In the presence of ammonium acetate buffer Is similar In both techniques. Doubly charged Ions are more often formed in thermospray and may reflect differences In the Ion formation mechanisms.",

author = "Catherine Fenselau and Liberato, {D. J.} and Yergey, {J. A.} and Cotter, {R. J.} and Yergey, {A. L.}",

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AU - Fenselau, Catherine

AU - Liberato, D. J.

AU - Yergey, J. A.

AU - Cotter, R. J.

AU - Yergey, A. L.

PY - 1984/12

Y1 - 1984/12

N2 - The effects of sample volatility, proton affinity, and charge on the mass spectra produced by the fast atom bombardment and thermospray Ionization techniques are compared. In general, the thermospray technique produced comparatively more fragmentation, while the dependence on sample proton affinity In the presence of ammonium acetate buffer Is similar In both techniques. Doubly charged Ions are more often formed in thermospray and may reflect differences In the Ion formation mechanisms.

AB - The effects of sample volatility, proton affinity, and charge on the mass spectra produced by the fast atom bombardment and thermospray Ionization techniques are compared. In general, the thermospray technique produced comparatively more fragmentation, while the dependence on sample proton affinity In the presence of ammonium acetate buffer Is similar In both techniques. Doubly charged Ions are more often formed in thermospray and may reflect differences In the Ion formation mechanisms.

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Comparison of Thermospray and Fast Atom Bombardment Mass Spectrometry as Solution-Dependent Ionization Techniques

Abstract

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