Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)

Daniel O. Clegg; Domenic J. Reda; Michael H. Weisman; John J. Cush; Frank B. Vasey; H. Ralph Schumacher; Elly Budiman-Mak; Dominic J. Balestra; Warren D. Blackburn; Grant W. Cannon; Robert D. Inman; F. Paul Alepa; Edwin Mejias; Miriam R. Cohen; Rama Makkena; Maren L. Mahowald; Jean Higashida; Stuart L. Silverman; Nourollah Parhami; Joel Buxbaum; Clair M. Haakenson; Richard H. Ward; B. J. Manaster; Robert J. Anderson; John R. Ward; William G. Henderson

doi:10.1002/art.1780391211

Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)

Daniel O. Clegg, Domenic J. Reda, Michael H. Weisman, John J. Cush, Frank B. Vasey, H. Ralph Schumacher, Elly Budiman-Mak, Dominic J. Balestra, Warren D. Blackburn, Grant W. Cannon, Robert D. Inman, F. Paul Alepa, Edwin Mejias, Miriam R. Cohen, Rama Makkena, Maren L. Mahowald, Jean Higashida, Stuart L. Silverman, Nourollah Parhami, Joel BuxbaumClair M. Haakenson, Richard H. Ward, B. J. Manaster, Robert J. Anderson, John R. Ward, William G. Henderson

Research output: Contribution to journal › Review article › peer-review

131 Scopus citations

Abstract

Objective. To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective in the treatment of reactive arthritis (ReA) that has been unresponsive to nonsteroidal antiinflammatory drug (NSAID) therapy. Methods. One hundred thirty-four patients with ReA who had failed to respond to NSAIDs were recruited from 19 clinics, randomized (double-blind) to receive either SSZ or placebo, and followed up for 36 weeks. The definition of treatment response was based on joint pain/tenderness and swelling scores and physician and patient global assessments. Results. Longitudinal analysis revealed improvement in the patients taking SSZ compared with those taking placebo, which appeared at 4 weeks and continued through the trial (P = 0.02). At the end of treatment, response rates were 62.3% for SSZ treatment compared with 47.7% for placebo treatment. The Westergren erythrocyte sedimentation rate declined more with SSZ treatment than with placebo (P < 0.0001). Adverse reactions were fewer than expected and were mainly due to nonspecific gastrointestinal complaints. Conclusion. SSZ at a dosage of 2,000 mg/day is well tolerated and effective in patients with chronically active ReA.

Original language	English (US)
Pages (from-to)	2021-2027
Number of pages	7
Journal	Arthritis and rheumatism
Volume	39
Issue number	12
DOIs	https://doi.org/10.1002/art.1780391211
State	Published - Dec 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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Clegg, D. O., Reda, D. J., Weisman, M. H., Cush, J. J., Vasey, F. B., Schumacher, H. R., Budiman-Mak, E., Balestra, D. J., Blackburn, W. D., Cannon, G. W., Inman, R. D., Alepa, F. P., Mejias, E., Cohen, M. R., Makkena, R., Mahowald, M. L., Higashida, J., Silverman, S. L., Parhami, N., ... Henderson, W. G. (1996). Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome). Arthritis and rheumatism, 39(12), 2021-2027. https://doi.org/10.1002/art.1780391211

Clegg, DO, Reda, DJ, Weisman, MH, Cush, JJ, Vasey, FB, Schumacher, HR, Budiman-Mak, E, Balestra, DJ, Blackburn, WD, Cannon, GW, Inman, RD, Alepa, FP, Mejias, E, Cohen, MR, Makkena, R, Mahowald, ML, Higashida, J, Silverman, SL, Parhami, N, Buxbaum, J, Haakenson, CM, Ward, RH, Manaster, BJ, Anderson, RJ, Ward, JR & Henderson, WG 1996, 'Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)', Arthritis and rheumatism, vol. 39, no. 12, pp. 2021-2027. https://doi.org/10.1002/art.1780391211

@article{31f36494de8743bb8d1685113abe224f,

title = "Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)",

abstract = "Objective. To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective in the treatment of reactive arthritis (ReA) that has been unresponsive to nonsteroidal antiinflammatory drug (NSAID) therapy. Methods. One hundred thirty-four patients with ReA who had failed to respond to NSAIDs were recruited from 19 clinics, randomized (double-blind) to receive either SSZ or placebo, and followed up for 36 weeks. The definition of treatment response was based on joint pain/tenderness and swelling scores and physician and patient global assessments. Results. Longitudinal analysis revealed improvement in the patients taking SSZ compared with those taking placebo, which appeared at 4 weeks and continued through the trial (P = 0.02). At the end of treatment, response rates were 62.3% for SSZ treatment compared with 47.7% for placebo treatment. The Westergren erythrocyte sedimentation rate declined more with SSZ treatment than with placebo (P < 0.0001). Adverse reactions were fewer than expected and were mainly due to nonspecific gastrointestinal complaints. Conclusion. SSZ at a dosage of 2,000 mg/day is well tolerated and effective in patients with chronically active ReA.",

author = "Clegg, {Daniel O.} and Reda, {Domenic J.} and Weisman, {Michael H.} and Cush, {John J.} and Vasey, {Frank B.} and Schumacher, {H. Ralph} and Elly Budiman-Mak and Balestra, {Dominic J.} and Blackburn, {Warren D.} and Cannon, {Grant W.} and Inman, {Robert D.} and Alepa, {F. Paul} and Edwin Mejias and Cohen, {Miriam R.} and Rama Makkena and Mahowald, {Maren L.} and Jean Higashida and Silverman, {Stuart L.} and Nourollah Parhami and Joel Buxbaum and Haakenson, {Clair M.} and Ward, {Richard H.} and Manaster, {B. J.} and Anderson, {Robert J.} and Ward, {John R.} and Henderson, {William G.}",

year = "1996",

month = dec,

doi = "10.1002/art.1780391211",

language = "English (US)",

volume = "39",

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journal = "Arthritis and rheumatism",

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TY - JOUR

T1 - Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)

AU - Clegg, Daniel O.

AU - Reda, Domenic J.

AU - Weisman, Michael H.

AU - Cush, John J.

AU - Vasey, Frank B.

AU - Schumacher, H. Ralph

AU - Budiman-Mak, Elly

AU - Balestra, Dominic J.

AU - Blackburn, Warren D.

AU - Cannon, Grant W.

AU - Inman, Robert D.

AU - Alepa, F. Paul

AU - Mejias, Edwin

AU - Cohen, Miriam R.

AU - Makkena, Rama

AU - Mahowald, Maren L.

AU - Higashida, Jean

AU - Silverman, Stuart L.

AU - Parhami, Nourollah

AU - Buxbaum, Joel

AU - Haakenson, Clair M.

AU - Ward, Richard H.

AU - Manaster, B. J.

AU - Anderson, Robert J.

AU - Ward, John R.

AU - Henderson, William G.

PY - 1996/12

Y1 - 1996/12

N2 - Objective. To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective in the treatment of reactive arthritis (ReA) that has been unresponsive to nonsteroidal antiinflammatory drug (NSAID) therapy. Methods. One hundred thirty-four patients with ReA who had failed to respond to NSAIDs were recruited from 19 clinics, randomized (double-blind) to receive either SSZ or placebo, and followed up for 36 weeks. The definition of treatment response was based on joint pain/tenderness and swelling scores and physician and patient global assessments. Results. Longitudinal analysis revealed improvement in the patients taking SSZ compared with those taking placebo, which appeared at 4 weeks and continued through the trial (P = 0.02). At the end of treatment, response rates were 62.3% for SSZ treatment compared with 47.7% for placebo treatment. The Westergren erythrocyte sedimentation rate declined more with SSZ treatment than with placebo (P < 0.0001). Adverse reactions were fewer than expected and were mainly due to nonspecific gastrointestinal complaints. Conclusion. SSZ at a dosage of 2,000 mg/day is well tolerated and effective in patients with chronically active ReA.

AB - Objective. To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective in the treatment of reactive arthritis (ReA) that has been unresponsive to nonsteroidal antiinflammatory drug (NSAID) therapy. Methods. One hundred thirty-four patients with ReA who had failed to respond to NSAIDs were recruited from 19 clinics, randomized (double-blind) to receive either SSZ or placebo, and followed up for 36 weeks. The definition of treatment response was based on joint pain/tenderness and swelling scores and physician and patient global assessments. Results. Longitudinal analysis revealed improvement in the patients taking SSZ compared with those taking placebo, which appeared at 4 weeks and continued through the trial (P = 0.02). At the end of treatment, response rates were 62.3% for SSZ treatment compared with 47.7% for placebo treatment. The Westergren erythrocyte sedimentation rate declined more with SSZ treatment than with placebo (P < 0.0001). Adverse reactions were fewer than expected and were mainly due to nonspecific gastrointestinal complaints. Conclusion. SSZ at a dosage of 2,000 mg/day is well tolerated and effective in patients with chronically active ReA.

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SN - 0004-3591

VL - 39

SP - 2021

EP - 2027

JO - Arthritis and rheumatism

JF - Arthritis and rheumatism

IS - 12

ER -

Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)

Abstract

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