Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils

Subechhya Pradhan; Susanne Bonekamp; Joseph S. Gillen; Laura M. Rowland; S. Andrea Wijtenburg; Richard A.E. Edden; Peter B. Barker

doi:10.1016/j.mri.2015.06.003

Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils

Subechhya Pradhan, Susanne Bonekamp, Joseph S. Gillen, Laura M. Rowland, S. Andrea Wijtenburg, Richard A.E. Edden, Peter B. Barker

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Purpose: The purpose of this study was to compare magnetic resonance spectroscopy (MRS) of three different regions of the human brain between 3 and 7 Tesla, using the same subjects and closely matched methodology at both field strengths. Methods: A semi-LASER (sLASER) pulse sequence with TE 32 ms was used to acquire metabolite spectrum along with the water reference at 3 T and 7 T using similar experimental parameters and hardware at both field strengths (n=4 per region and field). Spectra were analyzed in LCModel using a simulated basis set. Results: Signal-to-noise ratio (SNR) at 7 T was higher compared to 3 T, and linewidths (in ppm) at both field strengths were comparable in ppm scale. Of the 13 metabolites reported in the paper, most metabolites were measured with higher precision at 7 T in all three regions. Conclusion: The study confirms gains in SNR and measurement precision at 7 T in all three representative brain regions using the sLASER pulse sequence coupled with a 32-channel phased-array head coil.

Original language	English (US)
Pages (from-to)	1013-1018
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	33
Issue number	8
DOIs	https://doi.org/10.1016/j.mri.2015.06.003
State	Published - Oct 1 2015

Keywords

3 Tesla
7 Tesla
Brain
Magnetic resonance spectroscopy
Semi-LASER

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/j.mri.2015.06.003

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title = "Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils",

abstract = "Purpose: The purpose of this study was to compare magnetic resonance spectroscopy (MRS) of three different regions of the human brain between 3 and 7 Tesla, using the same subjects and closely matched methodology at both field strengths. Methods: A semi-LASER (sLASER) pulse sequence with TE 32 ms was used to acquire metabolite spectrum along with the water reference at 3 T and 7 T using similar experimental parameters and hardware at both field strengths (n=4 per region and field). Spectra were analyzed in LCModel using a simulated basis set. Results: Signal-to-noise ratio (SNR) at 7 T was higher compared to 3 T, and linewidths (in ppm) at both field strengths were comparable in ppm scale. Of the 13 metabolites reported in the paper, most metabolites were measured with higher precision at 7 T in all three regions. Conclusion: The study confirms gains in SNR and measurement precision at 7 T in all three representative brain regions using the sLASER pulse sequence coupled with a 32-channel phased-array head coil.",

keywords = "3 Tesla, 7 Tesla, Brain, Magnetic resonance spectroscopy, Semi-LASER",

author = "Subechhya Pradhan and Susanne Bonekamp and Gillen, {Joseph S.} and Rowland, {Laura M.} and Wijtenburg, {S. Andrea} and Edden, {Richard A.E.} and Barker, {Peter B.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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doi = "10.1016/j.mri.2015.06.003",

language = "English (US)",

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AU - Pradhan, Subechhya

AU - Bonekamp, Susanne

AU - Gillen, Joseph S.

AU - Rowland, Laura M.

AU - Wijtenburg, S. Andrea

AU - Edden, Richard A.E.

AU - Barker, Peter B.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Purpose: The purpose of this study was to compare magnetic resonance spectroscopy (MRS) of three different regions of the human brain between 3 and 7 Tesla, using the same subjects and closely matched methodology at both field strengths. Methods: A semi-LASER (sLASER) pulse sequence with TE 32 ms was used to acquire metabolite spectrum along with the water reference at 3 T and 7 T using similar experimental parameters and hardware at both field strengths (n=4 per region and field). Spectra were analyzed in LCModel using a simulated basis set. Results: Signal-to-noise ratio (SNR) at 7 T was higher compared to 3 T, and linewidths (in ppm) at both field strengths were comparable in ppm scale. Of the 13 metabolites reported in the paper, most metabolites were measured with higher precision at 7 T in all three regions. Conclusion: The study confirms gains in SNR and measurement precision at 7 T in all three representative brain regions using the sLASER pulse sequence coupled with a 32-channel phased-array head coil.

AB - Purpose: The purpose of this study was to compare magnetic resonance spectroscopy (MRS) of three different regions of the human brain between 3 and 7 Tesla, using the same subjects and closely matched methodology at both field strengths. Methods: A semi-LASER (sLASER) pulse sequence with TE 32 ms was used to acquire metabolite spectrum along with the water reference at 3 T and 7 T using similar experimental parameters and hardware at both field strengths (n=4 per region and field). Spectra were analyzed in LCModel using a simulated basis set. Results: Signal-to-noise ratio (SNR) at 7 T was higher compared to 3 T, and linewidths (in ppm) at both field strengths were comparable in ppm scale. Of the 13 metabolites reported in the paper, most metabolites were measured with higher precision at 7 T in all three regions. Conclusion: The study confirms gains in SNR and measurement precision at 7 T in all three representative brain regions using the sLASER pulse sequence coupled with a 32-channel phased-array head coil.

KW - 3 Tesla

KW - 7 Tesla

KW - Brain

KW - Magnetic resonance spectroscopy

KW - Semi-LASER

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Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils

Abstract

Keywords

ASJC Scopus subject areas

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