Comparison of scatter compensation strategies for myocardial perfusion imaging using Tc-99m labeled sestamibi

Yigal S. Gur, Troy H. Farncombe, P. Hendrik Pretorius, Howard C. Gifford, Manoj V. Narayanan, Eric C. Frey, Daniel Gagnon, Michael A. King

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Scatter can be a confounding problem in the detection of perfusion defects in myocardial perfusion imaging. The goal of this investigation was to compare practical methods of scatter compensation representing different classes of compensation strategies. The methods investigated were: 1) modification of the energy window; 2) use of effective values of attenuation coefficients; 3) estimating the scatter distribution from energy spectrum information; and 4) estimating the scatter distribution in the spatial domain using the attenuation maps and scatter kernels. Monte Carlo simulated projections from two MCAT source distributions were used to investigate the impact of the various methods on residual scatter and myocardial uniformity. The investigation showed that each of the methods reduce the scatter significantly; however, the spatial domain method gave the least variation with the different source distributions and the best uniformity.

Original languageEnglish (US)
Pages (from-to)2309-2314
Number of pages6
JournalIEEE Transactions on Nuclear Science
Volume49 I
Issue number5
StatePublished - Oct 2002
Externally publishedYes


  • Cardiac
  • Scatter compensation

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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