Comparison of network-based pathway analysis methods

Jason A. Papin, Joerg Stelling, Nathan D. Price, Steffen Klamt, Stefan Schuster, Bernhard O. Palsson

Research output: Contribution to journalArticlepeer-review

267 Scopus citations


Network-based definitions of biochemical pathways have emerged in recent years. These pathway definitions insist on the balanced use of a whole network of biochemical reactions. Two such related definitions, elementary modes and extreme pathways, have generated novel hypotheses regarding biochemical network function. The relationship between these two approaches can be illustrated by comparing and contrasting the elementary modes and extreme pathways of previously published metabolic reconstructions of the human red blood cell (RBC) and the human pathogen Helicobacter pylori. Descriptions of network properties generated by using these two approaches in the analysis of realistic metabolic networks need careful interpretation.

Original languageEnglish (US)
Pages (from-to)400-405
Number of pages6
JournalTrends in Biotechnology
Issue number8
StatePublished - Aug 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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