Comparison of human metapneumovirus infection with respiratory syncytial virus infection in children

Sean X. Zhang; Raymond Tellier; Rubeena Zafar; Rose Cheung; Dena Adachi; Susan E. Richardson

doi:10.1097/INF.0b013e3181aa6853

Comparison of human metapneumovirus infection with respiratory syncytial virus infection in children

Sean X. Zhang, Raymond Tellier, Rubeena Zafar, Rose Cheung, Dena Adachi, Susan E. Richardson

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We aimed to validate a direct immunofluorescence assay (DFA) for the detection of human metapneumovirus (hMPV) from nasal swabs and to determine the incidence and clinical features of this viral infection in a pediatric population. One hundred twenty-one of 3026 nasal swabs were positive for hMPV by DFA (4.0%). Compared with reverse transcriptase polymerase chain reaction, the sensitivity and specificity of DFA were 90%, and 100%, respectively. Compared with RSV, hMPV infection was more common in children with congenital abnormalities, particularly those with cardio-pulmonary dysplasia and was associated with an increased ventilatory requirement.

Original language	English (US)
Pages (from-to)	1022-1024
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	28
Issue number	11
DOIs	https://doi.org/10.1097/INF.0b013e3181aa6853
State	Published - Nov 2009
Externally published	Yes

Keywords

Human metapneumovirus
Respiratory syncytial virus

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0b013e3181aa6853

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AU - Tellier, Raymond

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AU - Cheung, Rose

AU - Adachi, Dena

AU - Richardson, Susan E.

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AB - We aimed to validate a direct immunofluorescence assay (DFA) for the detection of human metapneumovirus (hMPV) from nasal swabs and to determine the incidence and clinical features of this viral infection in a pediatric population. One hundred twenty-one of 3026 nasal swabs were positive for hMPV by DFA (4.0%). Compared with reverse transcriptase polymerase chain reaction, the sensitivity and specificity of DFA were 90%, and 100%, respectively. Compared with RSV, hMPV infection was more common in children with congenital abnormalities, particularly those with cardio-pulmonary dysplasia and was associated with an increased ventilatory requirement.

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Comparison of human metapneumovirus infection with respiratory syncytial virus infection in children

Abstract

Keywords

ASJC Scopus subject areas

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