Comparison of high titer Edmonston-Zagreb, Biken-CAM and Schwarz measles vaccines in Peruvian infants

Susan Berry, Herminio Hernandez, Rosa Kanashiro, Miquel Campos, Veronica Azabache, Grimanesa Gomez, Manuel Gutierrez, Brook Weirs, Ciro D. De quadros, Neal Halsey

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


In an effort to identify the optimal dose and strain of measles vaccination for early immunization, Peruvian infants were randomly assigned to receive one of three measles vaccines in varying doses at 5 to 6 or 8 to 9 months of age. Edmonston-Zagreb vaccines were significantly (P < 0.001) more immunogenic than equivalent or higher titers of Schwarz or Biken-CAM vaccines as determined by neutralization antibody response 3 months after vaccination. Eighty-two percent of infants who received high titer Edmonston-Zagreb vaccine at 5 to 6 months of age developed protective concentrations of measles antibody, a response rate similar to that observed after standard titer Schwarz (81%) or high titer Biken-CAM vaccine (81%) at 8 to 9 months of age. No significant differences in the rates of fever, rash or other adverse events were noted by vaccine group 10 to 14 days after vaccination. Although the high titer vaccines are more immunogenic in young infants than standard vaccines, long term safety must be assured before these vaccines can be put into widespread use.

Original languageEnglish (US)
Pages (from-to)822-827
Number of pages6
JournalPediatric Infectious Disease Journal
Issue number10
StatePublished - Oct 1992


  • Biken-CAM
  • Edmonston-Zagreb
  • Immune response
  • Immunization
  • Maternal antibodies
  • Measles vaccine
  • Peru

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases


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