Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls

Slim Fellah; Chunwei Ying; Yan Wang; Kristin P. Guilliams; Melanie E. Fields; Yasheng Chen; Josiah Lewis; Amy Mirro; Rachel Cohen; Nkemdilim Igwe; Cihat Eldeniz; Dengrong Jiang; Hanzhang Lu; William J. Powers; Jin Moo Lee; Andria L. Ford; Hongyu An

doi:10.1177/0271678X241237072

Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls

Slim Fellah, Chunwei Ying, Yan Wang, Kristin P. Guilliams, Melanie E. Fields, Yasheng Chen, Josiah Lewis, Amy Mirro, Rachel Cohen, Nkemdilim Igwe, Cihat Eldeniz, Dengrong Jiang, Hanzhang Lu, William J. Powers, Jin Moo Lee, Andria L. Ford, Hongyu An

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD.

Original language	English (US)
Pages (from-to)	1404-1416
Number of pages	13
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	44
Issue number	8
DOIs	https://doi.org/10.1177/0271678X241237072
State	Published - Aug 2024

Keywords

Asymmetric spin echo
T2-relaxation-under-spin-tagging
magnetic resonance imaging
oxygen extraction fraction
sickle cell disease

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1177/0271678X241237072

Cite this

Fellah, S., Ying, C., Wang, Y., Guilliams, K. P., Fields, M. E., Chen, Y., Lewis, J., Mirro, A., Cohen, R., Igwe, N., Eldeniz, C., Jiang, D., Lu, H., Powers, W. J., Lee, J. M., Ford, A. L., & An, H. (2024). Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls. Journal of Cerebral Blood Flow and Metabolism, 44(8), 1404-1416. https://doi.org/10.1177/0271678X241237072

Fellah, S, Ying, C, Wang, Y, Guilliams, KP, Fields, ME, Chen, Y, Lewis, J, Mirro, A, Cohen, R, Igwe, N, Eldeniz, C, Jiang, D , Lu, H, Powers, WJ, Lee, JM, Ford, AL & An, H 2024, 'Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls', Journal of Cerebral Blood Flow and Metabolism, vol. 44, no. 8, pp. 1404-1416. https://doi.org/10.1177/0271678X241237072

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title = "Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls",

abstract = "Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD.",

keywords = "Asymmetric spin echo, T2-relaxation-under-spin-tagging, magnetic resonance imaging, oxygen extraction fraction, sickle cell disease",

author = "Slim Fellah and Chunwei Ying and Yan Wang and Guilliams, {Kristin P.} and Fields, {Melanie E.} and Yasheng Chen and Josiah Lewis and Amy Mirro and Rachel Cohen and Nkemdilim Igwe and Cihat Eldeniz and Dengrong Jiang and Hanzhang Lu and Powers, {William J.} and Lee, {Jin Moo} and Ford, {Andria L.} and Hongyu An",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = aug,

doi = "10.1177/0271678X241237072",

language = "English (US)",

volume = "44",

pages = "1404--1416",

journal = "Journal of Cerebral Blood Flow and Metabolism",

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T1 - Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls

AU - Fellah, Slim

AU - Ying, Chunwei

AU - Wang, Yan

AU - Guilliams, Kristin P.

AU - Fields, Melanie E.

AU - Chen, Yasheng

AU - Lewis, Josiah

AU - Mirro, Amy

AU - Cohen, Rachel

AU - Igwe, Nkemdilim

AU - Eldeniz, Cihat

AU - Jiang, Dengrong

AU - Lu, Hanzhang

AU - Powers, William J.

AU - Lee, Jin Moo

AU - Ford, Andria L.

AU - An, Hongyu

PY - 2024/8

Y1 - 2024/8

N2 - Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD.

AB - Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD.

KW - Asymmetric spin echo

KW - T2-relaxation-under-spin-tagging

KW - magnetic resonance imaging

KW - oxygen extraction fraction

KW - sickle cell disease

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JO - Journal of Cerebral Blood Flow and Metabolism

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ER -

Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls

Abstract

Keywords

ASJC Scopus subject areas

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