Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: A preliminary study

Kevin M. Antshel; Stephen V. Faraone; Wanda Fremont; Michael C. Monuteaux; Wendy R. Kates; Alysa Doyle; Eric Mick; Joseph Biederman

doi:10.1177/1087054707299397

Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: A preliminary study

Kevin M. Antshel, Stephen V. Faraone, Wanda Fremont, Michael C. Monuteaux, Wendy R. Kates, Alysa Doyle, Eric Mick, Joseph Biederman

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Objective: Background: Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD). Method: The authors compared youth with VCFS+ADHD (from the SUNY Upstate VCFS Research Program) to those with ADHD but not VCFS (from the Massachusetts General Hospital Longitudinal Family Studies of ADHD). Results: Children with VCFS+ADHD were more likely to be diagnosed with the inattentive subtype and differed from idiopathic ADHD in the frequency of several inattentive symptoms that appear linked to general cognitive functioning. After controlling for IQ differences, parents of children with VCFS+ADHD endorsed more thought and social problems on a rating checklist. Patterns of comorbidity also differed between the two groups of children with ADHD: Children with idiopathic ADHD had higher rates of comorbid major depression and disruptive behavior disorders. Conclusion: Children with VCFS+ADHD may have a different profile of ADHD symptoms and comorbidity when compared to children with idiopathic ADHD. (J. of Att. Dis. 2007; 11(1) 64-73)

Original language	English (US)
Pages (from-to)	64-73
Number of pages	10
Journal	Journal of Attention Disorders
Volume	11
Issue number	1
DOIs	https://doi.org/10.1177/1087054707299397
State	Published - Aug 2007

Keywords

ADHD
Mental retardation
Velocardiofacial syndrome (VCFS)

ASJC Scopus subject areas

Developmental and Educational Psychology
Clinical Psychology

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10.1177/1087054707299397

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title = "Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: A preliminary study",

abstract = "Objective: Background: Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD). Method: The authors compared youth with VCFS+ADHD (from the SUNY Upstate VCFS Research Program) to those with ADHD but not VCFS (from the Massachusetts General Hospital Longitudinal Family Studies of ADHD). Results: Children with VCFS+ADHD were more likely to be diagnosed with the inattentive subtype and differed from idiopathic ADHD in the frequency of several inattentive symptoms that appear linked to general cognitive functioning. After controlling for IQ differences, parents of children with VCFS+ADHD endorsed more thought and social problems on a rating checklist. Patterns of comorbidity also differed between the two groups of children with ADHD: Children with idiopathic ADHD had higher rates of comorbid major depression and disruptive behavior disorders. Conclusion: Children with VCFS+ADHD may have a different profile of ADHD symptoms and comorbidity when compared to children with idiopathic ADHD. (J. of Att. Dis. 2007; 11(1) 64-73)",

keywords = "ADHD, Mental retardation, Velocardiofacial syndrome (VCFS)",

author = "Antshel, {Kevin M.} and Faraone, {Stephen V.} and Wanda Fremont and Monuteaux, {Michael C.} and Kates, {Wendy R.} and Alysa Doyle and Eric Mick and Joseph Biederman",

year = "2007",

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AU - Faraone, Stephen V.

AU - Fremont, Wanda

AU - Monuteaux, Michael C.

AU - Kates, Wendy R.

AU - Doyle, Alysa

AU - Mick, Eric

AU - Biederman, Joseph

PY - 2007/8

Y1 - 2007/8

N2 - Objective: Background: Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD). Method: The authors compared youth with VCFS+ADHD (from the SUNY Upstate VCFS Research Program) to those with ADHD but not VCFS (from the Massachusetts General Hospital Longitudinal Family Studies of ADHD). Results: Children with VCFS+ADHD were more likely to be diagnosed with the inattentive subtype and differed from idiopathic ADHD in the frequency of several inattentive symptoms that appear linked to general cognitive functioning. After controlling for IQ differences, parents of children with VCFS+ADHD endorsed more thought and social problems on a rating checklist. Patterns of comorbidity also differed between the two groups of children with ADHD: Children with idiopathic ADHD had higher rates of comorbid major depression and disruptive behavior disorders. Conclusion: Children with VCFS+ADHD may have a different profile of ADHD symptoms and comorbidity when compared to children with idiopathic ADHD. (J. of Att. Dis. 2007; 11(1) 64-73)

AB - Objective: Background: Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD). Method: The authors compared youth with VCFS+ADHD (from the SUNY Upstate VCFS Research Program) to those with ADHD but not VCFS (from the Massachusetts General Hospital Longitudinal Family Studies of ADHD). Results: Children with VCFS+ADHD were more likely to be diagnosed with the inattentive subtype and differed from idiopathic ADHD in the frequency of several inattentive symptoms that appear linked to general cognitive functioning. After controlling for IQ differences, parents of children with VCFS+ADHD endorsed more thought and social problems on a rating checklist. Patterns of comorbidity also differed between the two groups of children with ADHD: Children with idiopathic ADHD had higher rates of comorbid major depression and disruptive behavior disorders. Conclusion: Children with VCFS+ADHD may have a different profile of ADHD symptoms and comorbidity when compared to children with idiopathic ADHD. (J. of Att. Dis. 2007; 11(1) 64-73)

KW - ADHD

KW - Mental retardation

KW - Velocardiofacial syndrome (VCFS)

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Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: A preliminary study

Abstract

Keywords

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