Comparative physiological disposition of melatonin and its benzo[b]thiophene analog in the rat

Roger P. Maickel; Talmage R. Bosin; Steadman D. Harrison; Mark A. Riddle

doi:10.1016/0024-3205(74)90274-4

Comparative physiological disposition of melatonin and its benzo[b]thiophene analog in the rat

Roger P. Maickel, Talmage R. Bosin, Steadman D. Harrison, Mark A. Riddle

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Melatonin and its benzo[b]thiophene analog were labeled by acetylation of the corresponding 5-methoxyarylethylamines with ³H-acetic anhydride. The benzo[b]thiophene analog had a much higher lipid solubility. When administered to rats, both compounds disappeared from plasma and tissues by first-order decay. The dispositions were similar, with the higher lipid solubility of the benzo[b]thiophene analog resulting in higher tissue: plasma ratios, especially in adipose tissue, kidney and liver, and longer half-lives in plasma and tissues.

Original language	English (US)
Pages (from-to)	1735-1739
Number of pages	5
Journal	Life Sciences
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/0024-3205(74)90274-4
State	Published - May 1 1974
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(74)90274-4

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title = "Comparative physiological disposition of melatonin and its benzo[b]thiophene analog in the rat",

abstract = "Melatonin and its benzo[b]thiophene analog were labeled by acetylation of the corresponding 5-methoxyarylethylamines with 3H-acetic anhydride. The benzo[b]thiophene analog had a much higher lipid solubility. When administered to rats, both compounds disappeared from plasma and tissues by first-order decay. The dispositions were similar, with the higher lipid solubility of the benzo[b]thiophene analog resulting in higher tissue: plasma ratios, especially in adipose tissue, kidney and liver, and longer half-lives in plasma and tissues.",

author = "Maickel, {Roger P.} and Bosin, {Talmage R.} and Harrison, {Steadman D.} and Riddle, {Mark A.}",

note = "Funding Information: This research was supported in part by USPHS grants K02MH-41083 and NS-09762 and NASA grant NGL 15-003-117 .",

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T1 - Comparative physiological disposition of melatonin and its benzo[b]thiophene analog in the rat

AU - Maickel, Roger P.

AU - Bosin, Talmage R.

AU - Harrison, Steadman D.

AU - Riddle, Mark A.

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N2 - Melatonin and its benzo[b]thiophene analog were labeled by acetylation of the corresponding 5-methoxyarylethylamines with 3H-acetic anhydride. The benzo[b]thiophene analog had a much higher lipid solubility. When administered to rats, both compounds disappeared from plasma and tissues by first-order decay. The dispositions were similar, with the higher lipid solubility of the benzo[b]thiophene analog resulting in higher tissue: plasma ratios, especially in adipose tissue, kidney and liver, and longer half-lives in plasma and tissues.

AB - Melatonin and its benzo[b]thiophene analog were labeled by acetylation of the corresponding 5-methoxyarylethylamines with 3H-acetic anhydride. The benzo[b]thiophene analog had a much higher lipid solubility. When administered to rats, both compounds disappeared from plasma and tissues by first-order decay. The dispositions were similar, with the higher lipid solubility of the benzo[b]thiophene analog resulting in higher tissue: plasma ratios, especially in adipose tissue, kidney and liver, and longer half-lives in plasma and tissues.

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Comparative physiological disposition of melatonin and its benzo[b]thiophene analog in the rat

Abstract

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