Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Edward K. Chapnick; Jeremy D. Gradon; Barry Kreiswirth; Larry I. Lutwick; Benjamin C. Schaffer; Thomas D. Schiano; Michael H. Levi

doi:10.2307/30142381

Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Edward K. Chapnick, Jeremy D. Gradon, Barry Kreiswirth, Larry I. Lutwick, Benjamin C. Schaffer, Thomas D. Schiano, Michael H. Levi

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

Original language	English (US)
Pages (from-to)	178-180
Number of pages	3
Journal	Infection control and hospital epidemiology
Volume	17
Issue number	3
DOIs	https://doi.org/10.2307/30142381
State	Published - Mar 1996

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

Access to Document

10.2307/30142381

Cite this

@article{e583c06161b14f2a8a67f2001901c3bc,

title = "Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin",

abstract = "The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).",

author = "Chapnick, {Edward K.} and Gradon, {Jeremy D.} and Barry Kreiswirth and Lutwick, {Larry I.} and Schaffer, {Benjamin C.} and Schiano, {Thomas D.} and Levi, {Michael H.}",

year = "1996",

month = mar,

doi = "10.2307/30142381",

language = "English (US)",

volume = "17",

pages = "178--180",

journal = "Infection Control and Hospital Epidemiology",

issn = "0899-823X",

publisher = "University of Chicago Press",

number = "3",

}

TY - JOUR

T1 - Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

AU - Chapnick, Edward K.

AU - Gradon, Jeremy D.

AU - Kreiswirth, Barry

AU - Lutwick, Larry I.

AU - Schaffer, Benjamin C.

AU - Schiano, Thomas D.

AU - Levi, Michael H.

PY - 1996/3

Y1 - 1996/3

N2 - The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

AB - The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

UR - http://www.scopus.com/inward/record.url?scp=0030097078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030097078&partnerID=8YFLogxK

U2 - 10.2307/30142381

DO - 10.2307/30142381

M3 - Review article

C2 - 8708360

AN - SCOPUS:0030097078

SN - 0899-823X

VL - 17

SP - 178

EP - 180

JO - Infection Control and Hospital Epidemiology

JF - Infection Control and Hospital Epidemiology

IS - 3

ER -

Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this