Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Edward K. Chapnick; Jeremy D. Gradon; Barry Kreiswirth; Larry I. Lutwick; Benjamin C. Schaffer; Thomas D. Schiano; Michael H. Levi

doi:10.2307/30142381

Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Edward K. Chapnick, Jeremy D. Gradon, Barry Kreiswirth, Larry I. Lutwick, Benjamin C. Schaffer, Thomas D. Schiano, Michael H. Levi

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

Original language	English (US)
Pages (from-to)	178-180
Number of pages	3
Journal	Infection control and hospital epidemiology
Volume	17
Issue number	3
DOIs	https://doi.org/10.2307/30142381
State	Published - Mar 1996

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.2307/30142381

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title = "Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin",

abstract = "The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).",

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AU - Chapnick, Edward K.

AU - Gradon, Jeremy D.

AU - Kreiswirth, Barry

AU - Lutwick, Larry I.

AU - Schaffer, Benjamin C.

AU - Schiano, Thomas D.

AU - Levi, Michael H.

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AB - The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

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Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Abstract

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