Comparative histomorphological review of rat and human hepatocellular proliferative lesions

Bob Thoolen, Fiebo J.W. ten Kate, Paulus Joannes van Diest, David E. Malarkey, Susan A. Elmore, Robert R. Maronpot

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

Original languageEnglish (US)
Pages (from-to)189-199
Number of pages11
JournalJournal of Toxicologic Pathology
Issue number3
StatePublished - 2012
Externally publishedYes


  • Foci of cellular alteration
  • Hepatocellular adenoma
  • Hepatocellular carcinoma
  • Large cell change
  • Liver
  • Small cell change

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology


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