Comparative Effectiveness for Glycemic Control in Older Adults with Diabetes

Michael Quartuccio, Brian Buta, Rita Rastogi Kalyani

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Purpose of Review: The purpose of this review is to summarize the current data for comparative effectiveness of glycemic control in older adults. Recent Findings: In the last several years, professional societies have released guidelines for glycemic control in older adults, generally recommending individualized HbA1c goals. However, recent observational studies demonstrate that many older adults remain aggressively managed and are at increased risk of hypoglycemia. Large randomized trials of older adults with diabetes have failed to show convincing cardiovascular benefit from intensive glycemic control and suggest some microvascular benefit. Additionally, a few studies suggest that suboptimal glycemic control can increase the risk for geriatric syndromes. Emerging research suggests similar safety and efficacy of glucose-lowering therapies in older versus younger adults. Summary: Overall, there is a paucity of data supporting the benefit of intensive glycemic control in older adults. More research is needed in this vulnerable population.

Original languageEnglish (US)
Pages (from-to)175-186
Number of pages12
JournalCurrent Geriatrics Reports
Issue number3
StatePublished - Sep 1 2017


  • Age effects
  • Comparative effectiveness
  • Diabetes
  • Elderly
  • Geriatric
  • Glycemic control
  • Older adults

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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