Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates

Barun K. De; Michael D. Lairmore; Kevin Griffis; Laurina J. Williams; Francois Villinger; Thomas C. Quinn; Christopher Brown; Nzilambi; Mineharu Sugimoto; Shukuro Araki; Thomas M. Folks

doi:10.1016/0042-6822(91)90692-5

Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates

Barun K. De, Michael D. Lairmore, Kevin Griffis, Laurina J. Williams, Francois Villinger, Thomas C. Quinn, Christopher Brown, Nzilambi, Mineharu Sugimoto, Shukuro Araki, Thomas M. Folks

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31 Scopus citations

Abstract

Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMITSP). The nucleotide sequences of 640 by of the proviral genome (positions 5158-5797) derived from 11 HTLV-I-infected persons were analyzed using the polymerase chain reaction and M13-based sequencing techniques. Patterns of single nucleotide substitutions were characterized from the extracellular domain of the envelope gene (gp46). Compared with other retroviruses, the nucleotide sequences of the HTLV-I external envelope gene are highly conserved among the genotypes studied. We found no evidence of dual infections with HTLV-II among the seropositive asymptomatic persons or in patients with either ATL or HAMITSP. No unique sequence differences were observed in the envelope gene of the HTLV-I isolates derived from patients coinfected with human immunodeficiency virus type 1 (HIV-1). However, comparative analysis of these data and other published HTLV-I envelope sequences indicated the presence of four subtypes of HTLV-I in relation to their geographic origin.

Original language	English (US)
Pages (from-to)	413-419
Number of pages	7
Journal	Virology
Volume	182
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(91)90692-5
State	Published - May 1991
Externally published	Yes

ASJC Scopus subject areas

Virology

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De, B. K., Lairmore, M. D., Griffis, K., Williams, L. J., Villinger, F., Quinn, T. C., Brown, C., Nzilambi, Sugimoto, M., Araki, S., & Folks, T. M. (1991). Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates. Virology, 182(1), 413-419. https://doi.org/10.1016/0042-6822(91)90692-5

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title = "Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates",

abstract = "Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMITSP). The nucleotide sequences of 640 by of the proviral genome (positions 5158-5797) derived from 11 HTLV-I-infected persons were analyzed using the polymerase chain reaction and M13-based sequencing techniques. Patterns of single nucleotide substitutions were characterized from the extracellular domain of the envelope gene (gp46). Compared with other retroviruses, the nucleotide sequences of the HTLV-I external envelope gene are highly conserved among the genotypes studied. We found no evidence of dual infections with HTLV-II among the seropositive asymptomatic persons or in patients with either ATL or HAMITSP. No unique sequence differences were observed in the envelope gene of the HTLV-I isolates derived from patients coinfected with human immunodeficiency virus type 1 (HIV-1). However, comparative analysis of these data and other published HTLV-I envelope sequences indicated the presence of four subtypes of HTLV-I in relation to their geographic origin.",

author = "De, {Barun K.} and Lairmore, {Michael D.} and Kevin Griffis and Williams, {Laurina J.} and Francois Villinger and Quinn, {Thomas C.} and Christopher Brown and Nzilambi and Mineharu Sugimoto and Shukuro Araki and Folks, {Thomas M.}",

year = "1991",

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doi = "10.1016/0042-6822(91)90692-5",

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AU - Quinn, Thomas C.

AU - Brown, Christopher

AU - Nzilambi,

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AU - Araki, Shukuro

AU - Folks, Thomas M.

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N2 - Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMITSP). The nucleotide sequences of 640 by of the proviral genome (positions 5158-5797) derived from 11 HTLV-I-infected persons were analyzed using the polymerase chain reaction and M13-based sequencing techniques. Patterns of single nucleotide substitutions were characterized from the extracellular domain of the envelope gene (gp46). Compared with other retroviruses, the nucleotide sequences of the HTLV-I external envelope gene are highly conserved among the genotypes studied. We found no evidence of dual infections with HTLV-II among the seropositive asymptomatic persons or in patients with either ATL or HAMITSP. No unique sequence differences were observed in the envelope gene of the HTLV-I isolates derived from patients coinfected with human immunodeficiency virus type 1 (HIV-1). However, comparative analysis of these data and other published HTLV-I envelope sequences indicated the presence of four subtypes of HTLV-I in relation to their geographic origin.

AB - Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMITSP). The nucleotide sequences of 640 by of the proviral genome (positions 5158-5797) derived from 11 HTLV-I-infected persons were analyzed using the polymerase chain reaction and M13-based sequencing techniques. Patterns of single nucleotide substitutions were characterized from the extracellular domain of the envelope gene (gp46). Compared with other retroviruses, the nucleotide sequences of the HTLV-I external envelope gene are highly conserved among the genotypes studied. We found no evidence of dual infections with HTLV-II among the seropositive asymptomatic persons or in patients with either ATL or HAMITSP. No unique sequence differences were observed in the envelope gene of the HTLV-I isolates derived from patients coinfected with human immunodeficiency virus type 1 (HIV-1). However, comparative analysis of these data and other published HTLV-I envelope sequences indicated the presence of four subtypes of HTLV-I in relation to their geographic origin.

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Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates

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