Comparative Analysis of Computed Tomographic and Magnetic Resonance Imaging Scans in Alzheimer Patients and Controls

Tamas Sandor; Ferenc Jolesz; James Tieman; Ron Kikinis; Kenneth Jones; Marilyn Albert

doi:10.1001/archneur.1992.00530280069024

Comparative Analysis of Computed Tomographic and Magnetic Resonance Imaging Scans in Alzheimer Patients and Controls

Tamas Sandor, Ferenc Jolesz, James Tieman, Ron Kikinis, Kenneth Jones, Marilyn Albert

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Ten patients with Alzheimer's disease underwent computed tomography and magnetic resonance imaging at the same point in time. The mean Mini-Mental State examination score of the patients was 23, indicating that they were mildly impaired. Ten age-equivalent controls also obtained computed tomographic and magnetic resonance imaging scans. A semiautomated computer program analyzed nine comparable regions of interest on each set of scans. When regions of interest from both types of scans were combined in the same discriminant function analysis, the first two variables selected were from the magnetic resonance imaging data set, and they significantly differentiated 95% of the patients and controls.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Archives of neurology
Volume	49
Issue number	4
DOIs	https://doi.org/10.1001/archneur.1992.00530280069024
State	Published - Apr 1992
Externally published	Yes

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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AU - Tieman, James

AU - Kikinis, Ron

AU - Jones, Kenneth

AU - Albert, Marilyn

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AB - Ten patients with Alzheimer's disease underwent computed tomography and magnetic resonance imaging at the same point in time. The mean Mini-Mental State examination score of the patients was 23, indicating that they were mildly impaired. Ten age-equivalent controls also obtained computed tomographic and magnetic resonance imaging scans. A semiautomated computer program analyzed nine comparable regions of interest on each set of scans. When regions of interest from both types of scans were combined in the same discriminant function analysis, the first two variables selected were from the magnetic resonance imaging data set, and they significantly differentiated 95% of the patients and controls.

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Comparative Analysis of Computed Tomographic and Magnetic Resonance Imaging Scans in Alzheimer Patients and Controls

Abstract

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