TY - JOUR
T1 - Community-based treatment of onchocerciasis with ivermectin
T2 - Safety, efficacy, and acceptability of yearly treatment
AU - Pacqué, Michel
AU - Munoz, Beatriz
AU - Greene, Bruce M.
AU - Taylor, Hugh R.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/2
Y1 - 1991/2
N2 - The safety, acceptability, and efficacy of ivermectin during community-based mass treatment of onchocerciasis was assessed. Ivermectin was distributed three times, 1 year apart, to the population of a rubber plantation (14,000 people) in Liberia where >80% of adults have Onchocerca volvulus infection. In a sample of adults, the microfilarial density was reduced by 84% after 2 years of treatment. Acceptance was as high as 98% during the third year. Adverse reactions occurred in 6-13 in 1000 people after first treatment and in only 3-4 in 1000 receiving their second or third annual dose of ivermectin; severe adverse reactions were not seen. These data show that community-based treatment with ivermectin is safe, well accepted, and effective in reducing microfilarial loads and suggest that ivermectin is the first practical drug suitable for mass treatment campaigns to control human onchocerciasis.
AB - The safety, acceptability, and efficacy of ivermectin during community-based mass treatment of onchocerciasis was assessed. Ivermectin was distributed three times, 1 year apart, to the population of a rubber plantation (14,000 people) in Liberia where >80% of adults have Onchocerca volvulus infection. In a sample of adults, the microfilarial density was reduced by 84% after 2 years of treatment. Acceptance was as high as 98% during the third year. Adverse reactions occurred in 6-13 in 1000 people after first treatment and in only 3-4 in 1000 receiving their second or third annual dose of ivermectin; severe adverse reactions were not seen. These data show that community-based treatment with ivermectin is safe, well accepted, and effective in reducing microfilarial loads and suggest that ivermectin is the first practical drug suitable for mass treatment campaigns to control human onchocerciasis.
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U2 - 10.1093/infdis/163.2.381
DO - 10.1093/infdis/163.2.381
M3 - Article
C2 - 1988522
AN - SCOPUS:0026011670
SN - 0022-1899
VL - 163
SP - 381
EP - 385
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -