@inproceedings{071589372ec045b8b1a93e232c879998,
title = "Combining multiple knowledge sources: A case study of drug induced liver injury",
abstract = "Many classes of drugs, their interaction pathways and gene targets are known to play a role in drug induced liver injury (DILI). Pharmacogenomics research to understand the impact of genetic variation on how patients respond to drugs may help explain some of the variability observed in the occurrence of adverse drug reactions (ADR) such as DILI. The goal of this project is to combine rich genotype and phenotype data to better understand these scenarios. We consider similarities between drugs, similarities between drug targets, drug-pathway-gene interactions, etc. Links to the patients will include patient drug usage, ADR, disease outcomes, etc. We will develop appropriate protocols to create these rich datasets and methods to identify patterns in graphs for explanation and prediction.",
author = "Overby, {Casey L.} and Alejandro Flores and Guillermo Palma and Vidal, {Maria Esther} and Elena Zotkina and Louiqa Raschid",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; 11th International Conference on Data Integration in the Life Sciences, DILS 2015 ; Conference date: 09-07-2015 Through 10-07-2015",
year = "2015",
doi = "10.1007/978-3-319-21843-4_1",
language = "English (US)",
isbn = "9783319218427",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "3--12",
editor = "Jose-Luis Ambite and Naveen, {Ashish N.}",
booktitle = "Data Integration in the Life Sciences - 11th International Conference, DILS 2015, Proceedings",
}