Combining immunotherapy with radiation for the treatment of glioblastoma

Kevin K.H. Chow; Wendy Hara; Michael Lim; Gordon Li

doi:10.1007/s11060-015-1762-9

Combining immunotherapy with radiation for the treatment of glioblastoma

Kevin K.H. Chow, Wendy Hara, Michael Lim, Gordon Li

School of Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in GBM have thus far shown modest benefit. Optimally combining radiation with immunotherapy may be the key to unlocking the potential of both therapies given the evidence that radiation can enhance anti-tumor immunity. Here we review this evidence and discuss considerations for combined therapy.

Original language	English (US)
Pages (from-to)	459-464
Number of pages	6
Journal	Journal of neuro-oncology
Volume	123
Issue number	3
DOIs	https://doi.org/10.1007/s11060-015-1762-9
State	Published - Jul 23 2015

Keywords

Glioblastoma
Immunosuppression
Immunotherapy
Radiation therapy

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/s11060-015-1762-9

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abstract = "Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in GBM have thus far shown modest benefit. Optimally combining radiation with immunotherapy may be the key to unlocking the potential of both therapies given the evidence that radiation can enhance anti-tumor immunity. Here we review this evidence and discuss considerations for combined therapy.",

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AU - Hara, Wendy

AU - Lim, Michael

AU - Li, Gordon

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N2 - Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in GBM have thus far shown modest benefit. Optimally combining radiation with immunotherapy may be the key to unlocking the potential of both therapies given the evidence that radiation can enhance anti-tumor immunity. Here we review this evidence and discuss considerations for combined therapy.

AB - Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in GBM have thus far shown modest benefit. Optimally combining radiation with immunotherapy may be the key to unlocking the potential of both therapies given the evidence that radiation can enhance anti-tumor immunity. Here we review this evidence and discuss considerations for combined therapy.

KW - Glioblastoma

KW - Immunosuppression

KW - Immunotherapy

KW - Radiation therapy

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Combining immunotherapy with radiation for the treatment of glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

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