Combined T2-preparation and two-dimensional pencil-beam inner volume selection

Andrew J. Coristine, Ruud B. Van Heeswijk, Matthias Stuber

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose To improve coronary magnetic resonance angiography (MRA) by combining a two-dimensional (2D) spatially selective radiofrequency (RF) pulse with a T2-preparation module ("2D-T2-Prep"). Methods An adiabatic T2-Prep was modified so that the first and last pulses were of differing spatial selectivity. The first RF pulse was replaced by a 2D pulse, such that a pencil-beam volume is excited. The last RF pulse remains nonselective, thus restoring the T2-prepared pencil-beam, while tipping the (formerly longitudinal) magnetization outside of the pencil-beam into the transverse plane, where it is then spoiled. Thus, only a cylinder of T2-prepared tissue remains for imaging. Numerical simulations were followed by phantom validation and in vivo coronary MRA, where the technique was quantitatively evaluated. Reduced field-of-view (rFoV) images were similarly studied. Results In vivo, full field-of-view 2D-T2-Prep significantly improved vessel sharpness as compared to conventional T2-Prep, without adversely affecting signal-to-noise (SNR) or contrast-to-noise ratios (CNR). It also reduced respiratory motion artifacts. In rFoV images, the SNR, CNR, and vessel sharpness decreased, although scan time reduction was 60%. Conclusion When compared with conventional T2-Prep, the 2D-T2-Prep improves vessel sharpness and decreases respiratory ghosting while preserving both SNR and CNR. It may also acquire rFoV images for accelerated data acquisition. Magn Reson Med 74:529-536, 2015.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Aug 1 2015


  • 2D
  • T-prep
  • adiabatic
  • coronary
  • inner volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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