TY - JOUR
T1 - Combined Therapeutic Penetrating Keratoplasty and Pars Plana Vitrectomy for the Treatment of Infectious Keratitis Endophthalmitis
T2 - Mexican Endophthalmitis Study Group Protocol 4
AU - Mexican Endophthalmitis Study Group (Mex-ESG)
AU - Velez-Montoya, Raul
AU - Rivera-Cortes, Mariana A.
AU - Ledesma-Gil, Gerardo
AU - Carranza-Casas, Mario
AU - Martinez, Jaime D.
AU - Levine, Harry
AU - Yanuzzi, Nicolas A.
AU - Amescua, Guillermo
AU - Ahmed, Ishrat
AU - Beatson, Bradley
AU - Akpek, Esen
AU - Arevalo, J. Fernando
AU - Fromow-Guerra, Jans
AU - Velez-Montoya, R.
AU - García-Aguirre, G.
AU - Salcedo-Villanueva, G.
AU - Fromow-Guerra, J.
AU - Guerrero-Naranjo, J. L.
AU - Morales-Canton, V.
AU - Dalma-Weiszhausz, J.
AU - Quiroz-Mercado, H.
AU - Jimenez-Sierra, J. M.
AU - Martinez-Castellanos, M. A.
AU - Soberon-Ventura, V.
AU - Cernichiaro, L.
AU - Rojas-Juarez, S.
AU - Ramirez-Estudillo, A.
AU - Hernández-Vázquez, A. Y.
AU - Ledesma-Gil, G.
AU - Graue-Weichers, F.
AU - Fulda-Graue, E.
AU - Ariza-Camacho, E.
AU - López-Bolaños, A.
AU - Rodríguez-Loaiza, J. L.
AU - Lozano-Rechy, D.
AU - Moreno-Paramo, D.
AU - Flores-Peredo, V.
AU - García-Franco, R.
AU - Ramirez-Neria, P.
AU - Mira-Lorenzo, X.
AU - Hernández-Da Mota, S.
AU - Bejar-Cornejo, F.
AU - Rodriguez-Valdez, P. J.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Purpose:The purpose of this study was to assess the role of combined surgical treatment of therapeutic penetrating keratoplasty and pars plana vitrectomy in the anatomical and functional outcome of infectious keratitis endophthalmitis.Methods:This study reviewed the medical records of 4 participating centers in the United States and Mexico. This study included patients with a clinical diagnosis of infectious keratitis endophthalmitis who had been treated with an early therapeutic penetrating keratoplasty and pars plana vitrectomy as the main treatment for endophthalmitis. From each medical record, the study retrieved demographic data, relevant medical and drug history, baseline clinical manifestation of endophthalmitis, best-corrected visual acuity, and the need for enucleation/evisceration for the control of the infection or any other reason through the follow-up.Results:The study included 48 patients (50.15 ± 20.6 years). The mean follow-up time was 13 ± 0.5 months. The mean best-corrected visual acuity at baseline was 2.1 ± 0.25 logarithm of the minimum angle of resolution. At month 12 was 2.09 ± 0.61 logarithm of the minimum angle of resolution (P = 0.9). The overall prevalence of enucleation/evisceration was 8.3% (95% confidence interval: 2.32%-19.98%). The prevalence of a vision of no-light perception was 20.8% (95% confidence interval: 2.32%-19.98%).Conclusions:Combined surgery for severe cases of infectious keratitis endophthalmitis eradicates the infection in most cases, while significantly improving the overall outcomes.
AB - Purpose:The purpose of this study was to assess the role of combined surgical treatment of therapeutic penetrating keratoplasty and pars plana vitrectomy in the anatomical and functional outcome of infectious keratitis endophthalmitis.Methods:This study reviewed the medical records of 4 participating centers in the United States and Mexico. This study included patients with a clinical diagnosis of infectious keratitis endophthalmitis who had been treated with an early therapeutic penetrating keratoplasty and pars plana vitrectomy as the main treatment for endophthalmitis. From each medical record, the study retrieved demographic data, relevant medical and drug history, baseline clinical manifestation of endophthalmitis, best-corrected visual acuity, and the need for enucleation/evisceration for the control of the infection or any other reason through the follow-up.Results:The study included 48 patients (50.15 ± 20.6 years). The mean follow-up time was 13 ± 0.5 months. The mean best-corrected visual acuity at baseline was 2.1 ± 0.25 logarithm of the minimum angle of resolution. At month 12 was 2.09 ± 0.61 logarithm of the minimum angle of resolution (P = 0.9). The overall prevalence of enucleation/evisceration was 8.3% (95% confidence interval: 2.32%-19.98%). The prevalence of a vision of no-light perception was 20.8% (95% confidence interval: 2.32%-19.98%).Conclusions:Combined surgery for severe cases of infectious keratitis endophthalmitis eradicates the infection in most cases, while significantly improving the overall outcomes.
KW - endophthalmitis
KW - infectious keratitis
KW - penetrating keratoplasty
KW - treatment
KW - vitrectomy
UR - http://www.scopus.com/inward/record.url?scp=85161840099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85161840099&partnerID=8YFLogxK
U2 - 10.1097/ICO.0000000000003114
DO - 10.1097/ICO.0000000000003114
M3 - Article
C2 - 36441843
AN - SCOPUS:85161840099
SN - 0277-3740
VL - 42
SP - 805
EP - 814
JO - Cornea
JF - Cornea
IS - 7
ER -