Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization

James C. Harris, John D. Newman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


This study provides evidence for the interaction between opiate and noradrenergic neuronal systems on primate vocal behavior. The rate of twitters produced by adult squirrel monkeys was increased in an additive or synergistic manner by the combined administration of the α2 adrenergic antagonist yohimbine and the opiate antagonist naloxone. Similar effects were not demonstrated on the isolation call. In addition, the drug combination led to an increase of autonomic symptoms. The anatomical localization of these findings and mechanism for the production of increased twitters requires further investigation.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number1
StatePublished - Sep 1988


  • Anxiety
  • Isolation call
  • Opiate
  • Separation anxiety
  • Squirrel monkey
  • Vocalization
  • α Adrenergic

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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