Combined functional and viability cardiac MR imaging in a single breathhold

El Sayed H. Ibrahim, Matthias Stuber, Dara L. Kraitchman, Robert G. Weiss, Nael F. Osman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The combination of cardiac viability and functional information enhances the identification of different heart tissues in the setting of ischemic heart disease. A method has recently been proposed for obtaining black-blood delayed-enhancement (DE) viability images using the stimulated-echo acquisition mode (STEAM) MRI pulse sequence in a single short breathhold. The method was validated against conventional inversion-recovery (IR) DE images for identifying regions of myocardial infarction (MI). The method was based on the acquisition of three consecutive images of the same anatomical slice. One image has T 1-weighted contrast in which infarction appears bright. The two other images are used to construct an anatomical image of the heart, which is combined with the first image to produce a black-blood viability image. However, using appropriate modulation and demodulation frequencies, the latter two images bear useful information about myocardial deformation that results in a cardiac strain-encoding (SENC) functional image. In this work, a method is proposed for obtaining three consecutive SENC images in a single acquisition that can be combined to produce a composite image of the heart, which shows both functional and viability information. The proposed technique reduces scan time by one-half, compared with separate acquisitions of functional and viability images, and alleviates misregistration problems caused by separate breathholds.

Original languageEnglish (US)
Pages (from-to)843-849
Number of pages7
JournalMagnetic resonance in medicine
Issue number4
StatePublished - Oct 2007


  • Cardiac
  • Delayed-enhancement
  • Function
  • MRI
  • SENC
  • Viability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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