Combinatorial immunotherapy: PD-1 may not be LAG-ing behind any more

Meghan E. Turnis; Alan J. Korma; Charles G. Drake; Dario A A Vignali

doi:10.4161/onci.20593

Combinatorial immunotherapy: PD-1 may not be LAG-ing behind any more

Meghan E. Turnis, Alan J. Korma, Charles G. Drake, Dario A A Vignali

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Cancer immunotherapy attempts to harness the immune system by breaking tolerance and generating a robust anticancer response. we have recently demonstrated a synergistic enhancement in tumor clearance following therapeutic, dual PD-1 and LAG-3 blockade. here, we discuss the implications of these fndings in the context of future combinatorial immunotherapeutic approaches.

Original language	English (US)
Pages (from-to)	1172-1174
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	7
DOIs	https://doi.org/10.4161/onci.20593
State	Published - 2012

Keywords

Cancer
CD152
CD223
CD279
CTLA-4
Immunotherapy
Ipilimumab
LAG-3
Lymphocyte
MDX-1106
PD-1
Synergy

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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10.4161/onci.20593

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abstract = "Cancer immunotherapy attempts to harness the immune system by breaking tolerance and generating a robust anticancer response. we have recently demonstrated a synergistic enhancement in tumor clearance following therapeutic, dual PD-1 and LAG-3 blockade. here, we discuss the implications of these fndings in the context of future combinatorial immunotherapeutic approaches.",

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T2 - PD-1 may not be LAG-ing behind any more

AU - Turnis, Meghan E.

AU - Korma, Alan J.

AU - Drake, Charles G.

AU - Vignali, Dario A A

PY - 2012

Y1 - 2012

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AB - Cancer immunotherapy attempts to harness the immune system by breaking tolerance and generating a robust anticancer response. we have recently demonstrated a synergistic enhancement in tumor clearance following therapeutic, dual PD-1 and LAG-3 blockade. here, we discuss the implications of these fndings in the context of future combinatorial immunotherapeutic approaches.

KW - Cancer

KW - CD152

KW - CD223

KW - CD279

KW - CTLA-4

KW - Immunotherapy

KW - Ipilimumab

KW - LAG-3

KW - Lymphocyte

KW - MDX-1106

KW - PD-1

KW - Synergy

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JO - OncoImmunology

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Combinatorial immunotherapy: PD-1 may not be LAG-ing behind any more

Abstract

Keywords

ASJC Scopus subject areas

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