Colorectal cancer screening and surveillance strategy for patients with Diamond Blackfan anemia: Preliminary recommendations from the Diamond Blackfan Anemia Registry

Jeffrey M. Lipton; Christine L.S. Molmenti; Maryam Hussain; Pooja Desai; Maria Florento; Eva Atsidaftos; Adrianna Vlachos

doi:10.1002/pbc.28984

Colorectal cancer screening and surveillance strategy for patients with Diamond Blackfan anemia: Preliminary recommendations from the Diamond Blackfan Anemia Registry

Jeffrey M. Lipton, Christine L.S. Molmenti, Maryam Hussain, Pooja Desai, Maria Florento, Eva Atsidaftos, Adrianna Vlachos

Research output: Contribution to journal › Article › peer-review

Abstract

Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome characterized by red cell failure, congenital anomalies, poor linear growth, and cancer predisposition. Two previous analyses from the Diamond Blackfan Anemia Registry have quantified DBA as a cancer predisposition syndrome of moderate cancer penetrance. Patients with DBA have a 4.8-fold higher relative risk of developing cancer with an overall cumulative incidence of 13.7% by age 45 years. The two most prevalent solid tumors are colorectal cancer (CRC) and osteogenic sarcoma. Current and evolving data support the institution of cancer screening and surveillance strategies for CRC in DBA.

Original language	English (US)
Article number	e28984
Journal	Pediatric Blood and Cancer
Volume	68
Issue number	8
DOIs	https://doi.org/10.1002/pbc.28984
State	Published - Aug 2021
Externally published	Yes

Keywords

cancer screening
cancer surveillance
Diamond Blackfan anemia
early onset colorectal cancer

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.28984

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Colorectal cancer screening and surveillance strategy for patients with Diamond Blackfan anemia: Preliminary recommendations from the Diamond Blackfan Anemia Registry. / Lipton, Jeffrey M.; Molmenti, Christine L.S.; Hussain, Maryam et al.
In: Pediatric Blood and Cancer, Vol. 68, No. 8, e28984, 08.2021.

Research output: Contribution to journal › Article › peer-review

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abstract = "Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome characterized by red cell failure, congenital anomalies, poor linear growth, and cancer predisposition. Two previous analyses from the Diamond Blackfan Anemia Registry have quantified DBA as a cancer predisposition syndrome of moderate cancer penetrance. Patients with DBA have a 4.8-fold higher relative risk of developing cancer with an overall cumulative incidence of 13.7% by age 45 years. The two most prevalent solid tumors are colorectal cancer (CRC) and osteogenic sarcoma. Current and evolving data support the institution of cancer screening and surveillance strategies for CRC in DBA.",

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AU - Florento, Maria

AU - Atsidaftos, Eva

AU - Vlachos, Adrianna

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Colorectal cancer screening and surveillance strategy for patients with Diamond Blackfan anemia: Preliminary recommendations from the Diamond Blackfan Anemia Registry

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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