Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

J. W R Mulder, Miguel Sewnath, Gja Offerhaus, St Pals, J. Oosting, Pm Kruyt, Wf Weidema, Ca Seldenrijk

Research output: Contribution to journalArticlepeer-review

298 Scopus citations


CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.

Original languageEnglish (US)
Pages (from-to)1470-1472
Number of pages3
JournalThe Lancet
Issue number8935
StatePublished - Nov 26 1994
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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