Color enhancement of multispectral MR images: Improving the visualization of subcortical structures

Julianna Ward, Vincent Magnotta, Nancy C. Andreasen, Wendy Ooteman, Peg Nopoulos, Ronald Pierson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Purpose: The current investigation was undertaken to evaluate a new method for creating MR multispectral color images, which we call "Superimages." They were developed to improve the delineation of small brain structures composed of mixed tissue types, such as the basal ganglia. Method: To qualitatively validate the method, visual comparisons were made of six unimodal and multispectral images, including the Superimage. Quantitative validation was undertaken by comparing the reliability values for parcellation of the globus pallidus (GP) using either a gray scale (TI-weighted) image or the Superimage. Results: Qualitative assessment of the Superimage revealed enhanced visualization of the GP, caudate, and putamen. Quantitative assessment resulted in good reliability for Superimage traces. Conclusion: The Superimage significantly improves both the visualization and the parcellation of structures visualized by MRI.

Original languageEnglish (US)
Pages (from-to)942-949
Number of pages8
JournalJournal of computer assisted tomography
Issue number6
StatePublished - 2001
Externally publishedYes


  • Basal ganglia
  • Globus pallidus
  • Magnetic resonance imaging, multispectral
  • Parcellation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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