Color and pulsed Doppler sonography, gray-scale imaging, and serum CA 125 in the assessment of adnexal disease

Mladen Predanic, Nikos Vlahos, Joseph A. Pennisi, Mamdouh Moukhtar, Fatma A. Aleem

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective: To compare color and pulsed Doppler sonography with gray- scale ultrasound imaging and serum CA 125 levels in establishing accurate preoperative diagnoses of adnexal masses. Methods: Medical records of 109 patients referred with preexisting adnexal lesions were reviewed retrospectively by comparing preoperative ultrasonic data (gray-scale imaging and color and pulsed Doppler findings) with serum CA 125 levels. Results: Eighty-three masses were removed surgically, confirming seven malignancies and 76 benign tumors, and 26 masses were followed; 19 regressed and 11 persisted. Color and pulsed Doppler sonography showed the highest sensitivity, followed by gray-scale imaging, whereas serum CA 125 levels revealed the highest specificity in distinguishing malignant from benign adnexal tumors. All three methods had high negative predictive values (96- 100%), whereas only serum CA 125 had a positive predictive value greater than 50%. Conclusion: Color and pulsed Doppler sonography, which demonstrate a tumor angiogenic activity, are as accurate as gray-scale imaging in the assessment of adnexal lesions. Together with serum CA 125 marker levels, they produce high negative predictive values, providing reassurance that an adnexal mass is benign.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalObstetrics and gynecology
Issue number2
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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