Cohort profile: Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study

Yufang Bi, Jieli Lu, Weiqing Wang, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Qin Wan, Shengli Wu, Tao Yang, Li Yan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan GaoQing Su, Zhen Ye, Youming Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Jie Zhang, Jichao Sun, Meng Dai, Min Xu, Yu Xu, Yuhong Chen, Shenghan Lai, Zachary T. Bloomgarden, Donghui Li, Guang Ning

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Objective: To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism. Methods: Between 2011 and 2012, 259657 community-dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland China to participant in the baseline survey of the REACTION study, with follow-up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio-samples including serum, urine, and whole blood for DNA extraction were collected for all the participants. Results: The mean ± standard deviation (SD) age of this cohort was 57±10 years. And the prevalence of pre-existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (PR) of stomach cancer (PR: 0.38, 95% CI: 0.16-0.89), and women with diabetes had significantly higher adjusted PRs of cancer of all sites (PR: 1.36, 95% CI: 1.20-1.56), and cancer of the breast (PR: 1.56, 95% CI: 1.21-2.00), the endometrium (PR: 1.58, 95% CI: 1.16-2.15), and the thyroid (PR: 1.53, 95% CI: 1.03-2.27). Conclusion: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259657 adults from the general population across the China.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalJournal of diabetes
Issue number2
StatePublished - Mar 2014
Externally publishedYes


  • Cancer
  • Diabetes
  • REACTION study

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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