Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Andreea M. Rawlings, Albert Richey Sharrett, Thomas H. Mosley, Dean F. Wong, David S. Knopman, Rebecca F. Gottesman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number2
StatePublished - 2019


  • Amyloid
  • PET imaging
  • cohort study
  • education
  • epidemiology
  • human

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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