TY - JOUR
T1 - Cognitive development among children with early-treated phenylketonuria
AU - Mazzocco, Michele M.M.
AU - Nord, Ann M.
AU - Doorninck, William Van
AU - Greene, Carol L.
AU - Kovar, Caryn G.
AU - Pennington, Bruce F.
N1 - Funding Information:
This research was supported by NICHD Mental Retardation Research Center, Grant No. HD04024; byGrant No. MCJ000252 from theU.S. Departmentof Health and Human Services, Bureau ofMaternal and Child Health; and byGrant No. RR69 from the NEH General Clinical Research Centers Program. Bruce F. Pennington was supported by NICHD Center Grant No. HD27802, NIMH Research Scientist Development Award No. MH00419, andMERIT AwardNo. MH38820.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Previous research supports the notion that children with early-treated classical phenylketonuria (PKU) have specific cognitive deficits in executive function skills. These deficits may relate to depressed levels of dopamine, due to defective tyrosine synthesis. We investigated whether deficits reported for preschoolers with early-treated PKU are manifested also among school-age children with PKU, and whether cognitive performance among the latter group is related to phenylalanine level at time of testing. Seventeen children with PKU and 17 age-, sex-, and IQ-matched controls were tested individually on measures of executive functions. The results demonstrate that executive function deficits reported for preschoolers with PKU were not manifested in the school-age PKU children included in this study. The authors discuss the implications of these findings for theories of the development of executive function skills.
AB - Previous research supports the notion that children with early-treated classical phenylketonuria (PKU) have specific cognitive deficits in executive function skills. These deficits may relate to depressed levels of dopamine, due to defective tyrosine synthesis. We investigated whether deficits reported for preschoolers with early-treated PKU are manifested also among school-age children with PKU, and whether cognitive performance among the latter group is related to phenylalanine level at time of testing. Seventeen children with PKU and 17 age-, sex-, and IQ-matched controls were tested individually on measures of executive functions. The results demonstrate that executive function deficits reported for preschoolers with PKU were not manifested in the school-age PKU children included in this study. The authors discuss the implications of these findings for theories of the development of executive function skills.
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U2 - 10.1080/87565649409540573
DO - 10.1080/87565649409540573
M3 - Article
AN - SCOPUS:0001568245
SN - 8756-5641
VL - 10
SP - 133
EP - 151
JO - Developmental Neuropsychology
JF - Developmental Neuropsychology
IS - 2
ER -