Cognitive abilities of patients with Lesch-Nyhan disease

Lowell T. Anderson, Monique Ernst, Susan V. Davis

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Parents of 42 patients with Lesch-Nyhan disease completed a questionnaire systematizing caregiver observations of the subject's behavior during a wide variety of daily events. Responses were grouped in nine categories reflecting different aspects of cognitive skills. Only 1 boy appears to have any significant generalized cognitive impairment. The patients' memory for both recent and past events is excellent, their emotional life has a normal range of reactions and is appropriate; they have good concentration, are capable of abstract reasoning, have good self-awareness, and are highly social. However, they are behind in academic ability, with only 15% at grade level for math and reading. Implications for designing educational activities, parenting or caregiver strategies, and research methodology are discussed.

Original languageEnglish (US)
Pages (from-to)189-203
Number of pages15
JournalJournal of Autism and Developmental Disorders
Issue number2
StatePublished - Jun 1992
Externally publishedYes

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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