Cogelation of Hydrolyzable Cross-Linkers and Poly(ethylene oxide) Dimethacrylate and Their Use as Controlled Release Vehicles

Jennifer Elisseeff; Winnette McIntosh; Kristi Anseth; Robert Langer

doi:10.1021/bk-1999-0728.ch001

Cogelation of Hydrolyzable Cross-Linkers and Poly(ethylene oxide) Dimethacrylate and Their Use as Controlled Release Vehicles

Jennifer Elisseeff, Winnette McIntosh, Kristi Anseth, Robert Langer

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Small molecular weight crosslinking agents containing hydrolyzable bonds were photopolymerized with poly(ethylene oxide) in order to decrease the pore size of the gels. The resulting cogels decreased in equilibrium swelling volume (pore size) as the concentration of crosslinker increased. The initial release profile of the model protein albumin showed a decreased burst in the presence of small molecular weight crosslinkers in the photopolymerized hydrogels.

Original language	English (US)
Pages (from-to)	1-13
Number of pages	13
Journal	ACS Symposium Series
Volume	728
DOIs	https://doi.org/10.1021/bk-1999-0728.ch001
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1021/bk-1999-0728.ch001

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title = "Cogelation of Hydrolyzable Cross-Linkers and Poly(ethylene oxide) Dimethacrylate and Their Use as Controlled Release Vehicles",

abstract = "Small molecular weight crosslinking agents containing hydrolyzable bonds were photopolymerized with poly(ethylene oxide) in order to decrease the pore size of the gels. The resulting cogels decreased in equilibrium swelling volume (pore size) as the concentration of crosslinker increased. The initial release profile of the model protein albumin showed a decreased burst in the presence of small molecular weight crosslinkers in the photopolymerized hydrogels.",

author = "Jennifer Elisseeff and Winnette McIntosh and Kristi Anseth and Robert Langer",

year = "1999",

doi = "10.1021/bk-1999-0728.ch001",

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AU - McIntosh, Winnette

AU - Anseth, Kristi

AU - Langer, Robert

PY - 1999

Y1 - 1999

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AB - Small molecular weight crosslinking agents containing hydrolyzable bonds were photopolymerized with poly(ethylene oxide) in order to decrease the pore size of the gels. The resulting cogels decreased in equilibrium swelling volume (pore size) as the concentration of crosslinker increased. The initial release profile of the model protein albumin showed a decreased burst in the presence of small molecular weight crosslinkers in the photopolymerized hydrogels.

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Cogelation of Hydrolyzable Cross-Linkers and Poly(ethylene oxide) Dimethacrylate and Their Use as Controlled Release Vehicles

Abstract

ASJC Scopus subject areas

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