Coevolution of cancer and stromal cellular responses

Laurie E. Littlepage; Mikala Egeblad; Zena Werb

doi:10.1016/j.ccr.2005.05.019

Coevolution of cancer and stromal cellular responses

Laurie E. Littlepage
, Mikala Egeblad
, Zena Werb

Research output: Contribution to journal › Short survey › peer-review

Abstract

It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.

Original language	English (US)
Pages (from-to)	499-500
Number of pages	2
Journal	Cancer cell
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/j.ccr.2005.05.019
State	Published - Jun 2005
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccr.2005.05.019

Cite this

@article{b35dc4d7d6fc42d19aae6312b62f700f,

title = "Coevolution of cancer and stromal cellular responses",

abstract = "It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.",

author = "Littlepage, \{Laurie E.\} and Mikala Egeblad and Zena Werb",

year = "2005",

month = jun,

doi = "10.1016/j.ccr.2005.05.019",

language = "English (US)",

volume = "7",

pages = "499--500",

journal = "Cancer cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "6",

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T1 - Coevolution of cancer and stromal cellular responses

AU - Littlepage, Laurie E.

AU - Egeblad, Mikala

AU - Werb, Zena

PY - 2005/6

Y1 - 2005/6

N2 - It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.

AB - It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.

UR - https://www.scopus.com/pages/publications/20444386530

UR - https://www.scopus.com/pages/publications/20444386530#tab=citedBy

U2 - 10.1016/j.ccr.2005.05.019

DO - 10.1016/j.ccr.2005.05.019

M3 - Short survey

C2 - 15950897

AN - SCOPUS:20444386530

SN - 1535-6108

VL - 7

SP - 499

EP - 500

JO - Cancer cell

JF - Cancer cell

IS - 6

ER -

Coevolution of cancer and stromal cellular responses

Abstract

ASJC Scopus subject areas

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