TY - JOUR
T1 - Coevolution of cancer and stromal cellular responses
AU - Littlepage, Laurie E.
AU - Egeblad, Mikala
AU - Werb, Zena
PY - 2005/6
Y1 - 2005/6
N2 - It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.
AB - It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1α (CXCL12). SDF-1α stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.
UR - http://www.scopus.com/inward/record.url?scp=20444386530&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20444386530&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2005.05.019
DO - 10.1016/j.ccr.2005.05.019
M3 - Short survey
C2 - 15950897
AN - SCOPUS:20444386530
SN - 1535-6108
VL - 7
SP - 499
EP - 500
JO - Cancer cell
JF - Cancer cell
IS - 6
ER -