Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

Frank J. Meye, Kristina Valentinova, Salvatore Lecca, Lucile Marion-Poll, Matthieu J. Maroteaux, Stefano Musardo, Imane Moutkine, Fabrizio Gardoni, Richard L. Huganir, François Georges, Manuel Mameli

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K + currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

Original languageEnglish (US)
Pages (from-to)376-380
Number of pages5
JournalNature neuroscience
Issue number3
StatePublished - Mar 27 2015

ASJC Scopus subject areas

  • Neuroscience(all)


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