@article{e032f1b52fdb434db05664a5fdf2cbe9,
title = "Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula",
abstract = "Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K + currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.",
author = "Meye, {Frank J.} and Kristina Valentinova and Salvatore Lecca and Lucile Marion-Poll and Maroteaux, {Matthieu J.} and Stefano Musardo and Imane Moutkine and Fabrizio Gardoni and Huganir, {Richard L.} and Fran{\c c}ois Georges and Manuel Mameli",
note = "Funding Information: We thank C. Bellone, M.T.C. Brown, C. L{\"u}scher and J.C. Poncer for discussions and comments on the manuscript. This work was supported by funds from the INSERM Atip-Avenir, ERC StG SalienSy 335333 and the Paris School of Neuroscience Network (ENP) to M.M., and the Agence Nationale de la Recherche (ANR-12-bsv4-0022-01) to F. Georges. F.J.M. is supported by a postdoctoral fellowship from the Fyssen Foundation and K.V. is supported by a PhD fellowship from the French Ministry of Science (ESR). Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
year = "2015",
month = mar,
day = "27",
doi = "10.1038/nn.3923",
language = "English (US)",
volume = "18",
pages = "376--380",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "3",
}