Cocaine enhances one-way avoidance responding in mice

Susan B. Weinberger; Cecilia A. Riedel; Patricia H. Janak; Joe L. Martinez

doi:10.1016/0091-3057(92)90238-B

Cocaine enhances one-way avoidance responding in mice

Susan B. Weinberger, Cecilia A. Riedel, Patricia H. Janak, Joe L. Martinez

Research output: Contribution to journal › Article › peer-review

Abstract

We reported previously that posttraining cocaine injections enhance subsequent performance of an automated jump-up avoidance response and trough avoidance response in rats. In the present study we examined the species generality of the cocaine enhancement by investigating the effects of posttraining cocaine injection on subsequent performance of a one-way active avoidance response in mice. Cocaine (30 mg/kg, IP) administered to mice immediately following completion of two escape-only trials on day 1 significantly enhanced avoidance response performance on day 2. Neither lidocaine nor cocaine methiodide, when administered in doses equimolar to the effective cocaine dose, altered performance on day 2. These data indicate that cocaine's enhancement of avoidance responding in mice probably is neither peripherally mediated nor attributable to its local anesthetic properties.

Original language	English (US)
Pages (from-to)	851-854
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(92)90238-B
State	Published - Apr 1992
Externally published	Yes

Keywords

Cocaine
Cocaine methiodide
Lidocaine
Memory
Mice
One-way active avoidance

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(92)90238-B

Cite this

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title = "Cocaine enhances one-way avoidance responding in mice",

abstract = "We reported previously that posttraining cocaine injections enhance subsequent performance of an automated jump-up avoidance response and trough avoidance response in rats. In the present study we examined the species generality of the cocaine enhancement by investigating the effects of posttraining cocaine injection on subsequent performance of a one-way active avoidance response in mice. Cocaine (30 mg/kg, IP) administered to mice immediately following completion of two escape-only trials on day 1 significantly enhanced avoidance response performance on day 2. Neither lidocaine nor cocaine methiodide, when administered in doses equimolar to the effective cocaine dose, altered performance on day 2. These data indicate that cocaine's enhancement of avoidance responding in mice probably is neither peripherally mediated nor attributable to its local anesthetic properties.",

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AU - Weinberger, Susan B.

AU - Riedel, Cecilia A.

AU - Janak, Patricia H.

AU - Martinez, Joe L.

PY - 1992/4

Y1 - 1992/4

N2 - We reported previously that posttraining cocaine injections enhance subsequent performance of an automated jump-up avoidance response and trough avoidance response in rats. In the present study we examined the species generality of the cocaine enhancement by investigating the effects of posttraining cocaine injection on subsequent performance of a one-way active avoidance response in mice. Cocaine (30 mg/kg, IP) administered to mice immediately following completion of two escape-only trials on day 1 significantly enhanced avoidance response performance on day 2. Neither lidocaine nor cocaine methiodide, when administered in doses equimolar to the effective cocaine dose, altered performance on day 2. These data indicate that cocaine's enhancement of avoidance responding in mice probably is neither peripherally mediated nor attributable to its local anesthetic properties.

AB - We reported previously that posttraining cocaine injections enhance subsequent performance of an automated jump-up avoidance response and trough avoidance response in rats. In the present study we examined the species generality of the cocaine enhancement by investigating the effects of posttraining cocaine injection on subsequent performance of a one-way active avoidance response in mice. Cocaine (30 mg/kg, IP) administered to mice immediately following completion of two escape-only trials on day 1 significantly enhanced avoidance response performance on day 2. Neither lidocaine nor cocaine methiodide, when administered in doses equimolar to the effective cocaine dose, altered performance on day 2. These data indicate that cocaine's enhancement of avoidance responding in mice probably is neither peripherally mediated nor attributable to its local anesthetic properties.

KW - Cocaine

KW - Cocaine methiodide

KW - Lidocaine

KW - Memory

KW - Mice

KW - One-way active avoidance

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Cocaine enhances one-way avoidance responding in mice

Abstract

Keywords

ASJC Scopus subject areas

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