Cocaine enhances one-way avoidance responding in mice

Susan B. Weinberger, Cecilia A. Riedel, Patricia H. Janak, Joe L. Martinez

Research output: Contribution to journalArticlepeer-review

Abstract

We reported previously that posttraining cocaine injections enhance subsequent performance of an automated jump-up avoidance response and trough avoidance response in rats. In the present study we examined the species generality of the cocaine enhancement by investigating the effects of posttraining cocaine injection on subsequent performance of a one-way active avoidance response in mice. Cocaine (30 mg/kg, IP) administered to mice immediately following completion of two escape-only trials on day 1 significantly enhanced avoidance response performance on day 2. Neither lidocaine nor cocaine methiodide, when administered in doses equimolar to the effective cocaine dose, altered performance on day 2. These data indicate that cocaine's enhancement of avoidance responding in mice probably is neither peripherally mediated nor attributable to its local anesthetic properties.

Original languageEnglish (US)
Pages (from-to)851-854
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume41
Issue number4
DOIs
StatePublished - Apr 1992
Externally publishedYes

Keywords

  • Cocaine
  • Cocaine methiodide
  • Lidocaine
  • Memory
  • Mice
  • One-way active avoidance

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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