Abstract
Mitochondria supply cellular energy through oxidative phosphorylation and fulfill numerous additional functions that are fundamental to cellular homeostasis and stress responses. Mitochondrial malfunction, arising from inherent defects of the organelle itself, aging, or acute or chronic stress, can cause substantial damage to organismal health. For instance, mitochondrial malfunction contributes to inflammation, neurodegeneration, tumorigenesis and cardiovascular diseases. Therefore, various quality control mechanisms exist that support a functional mitochondrial organelle compartment. The CMLS Forum Reviews introduced here present a collection of articles covering select topics on basic mechanisms and pathophysiological contexts of mitochondrial damage control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3763-3765 |
| Number of pages | 3 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 78 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 2021 |
Keywords
- Apoptosis
- Autophagy
- Mitochondria
- Mitochondrial dynamics
- Mitochondrial quality control
- Mitochondrial retrograde response
- Mitochondrial unfolded protein response
- Mitophagy
- Stress signaling
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology