TY - JOUR
T1 - Clustering of equine grass sickness cases in the United Kingdom
T2 - A study considering the effect of position-dependent reporting on the space-time K-function
AU - French, N. P.
AU - McCarthy, H. E.
AU - Diggle, P. J.
AU - Proudman, C. J.
PY - 2005/4
Y1 - 2005/4
N2 - Equine grass sickness (EGS) is a largely fatal, pasture-associated dysautonomia. Although the aetiology of this disease is unknown, there is increasing evidence that Clostridium botulinum type C plays an important role in this condition. The disease is widespread in the United Kingdom, with the highest incidence believed to occur in Scotland. EGS also shows strong seasonal variation (most cases are reported between April and July). Data from histologically confirmed cases of EGS from England and Wales in 1999 and 2000 were collected from UK veterinary diagnostic centres. The data did not represent a complete census of cases, and the proportion of all cases reported to the centres would have varied in space and, independently, in time. We consider the variable reporting of this condition and the appropriateness of the space-time K-function when exploring the spatial-temporal properties of a 'thinned' point process. We conclude that such position-dependent under-reporting of EGS does not invalidate the Monte Carlo test for space-time interaction, and find strong evidence for space-time clustering of EGS cases (P
AB - Equine grass sickness (EGS) is a largely fatal, pasture-associated dysautonomia. Although the aetiology of this disease is unknown, there is increasing evidence that Clostridium botulinum type C plays an important role in this condition. The disease is widespread in the United Kingdom, with the highest incidence believed to occur in Scotland. EGS also shows strong seasonal variation (most cases are reported between April and July). Data from histologically confirmed cases of EGS from England and Wales in 1999 and 2000 were collected from UK veterinary diagnostic centres. The data did not represent a complete census of cases, and the proportion of all cases reported to the centres would have varied in space and, independently, in time. We consider the variable reporting of this condition and the appropriateness of the space-time K-function when exploring the spatial-temporal properties of a 'thinned' point process. We conclude that such position-dependent under-reporting of EGS does not invalidate the Monte Carlo test for space-time interaction, and find strong evidence for space-time clustering of EGS cases (P
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U2 - 10.1017/S0950268804003322
DO - 10.1017/S0950268804003322
M3 - Article
C2 - 15816161
AN - SCOPUS:15944365833
SN - 0950-2688
VL - 133
SP - 343
EP - 348
JO - Epidemiology and Infection
JF - Epidemiology and Infection
IS - 2
ER -