Clozapine-induced late leukopenia

Z. Latif; M. A. Malik; F. Jabbar; Y. Ahmed; C. McDonough

doi:10.1007/s11845-010-0587-y

Clozapine-induced late leukopenia

Z. Latif, M. A. Malik, F. Jabbar, Y. Ahmed, C. McDonough

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A patient with a 28-year history of schizophrenia was treated with a wide range of antipsychotic medications since diagnosis. She had experienced no clinically significant symptomatic relief until she commenced treatment on clozapine. Her psychotic symptoms, self care, and general sense of well-being improved significantly. After 6 years of successful treatment, she developed leukopenia and clozapine was discontinued. The following issues will be discussed in the article: rechallenge with clozapine following leukopenia during previous therapy and the choice of and haematological monitoring needs with other antipsychotic medications after clozapineinduced blood dyscrasia.

Original language	English (US)
Pages (from-to)	139-141
Number of pages	3
Journal	Irish journal of medical science
Volume	181
Issue number	1
DOIs	https://doi.org/10.1007/s11845-010-0587-y
State	Published - Mar 2012
Externally published	Yes

Keywords

Agranulocytosis
Blood dyscrasia
Clozapine
Leukopenia
Neutropenia
Rechallenge with clozapine

ASJC Scopus subject areas

Medicine(all)

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10.1007/s11845-010-0587-y

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title = "Clozapine-induced late leukopenia",

abstract = "A patient with a 28-year history of schizophrenia was treated with a wide range of antipsychotic medications since diagnosis. She had experienced no clinically significant symptomatic relief until she commenced treatment on clozapine. Her psychotic symptoms, self care, and general sense of well-being improved significantly. After 6 years of successful treatment, she developed leukopenia and clozapine was discontinued. The following issues will be discussed in the article: rechallenge with clozapine following leukopenia during previous therapy and the choice of and haematological monitoring needs with other antipsychotic medications after clozapineinduced blood dyscrasia.",

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AU - Latif, Z.

AU - Malik, M. A.

AU - Jabbar, F.

AU - Ahmed, Y.

AU - McDonough, C.

PY - 2012/3

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N2 - A patient with a 28-year history of schizophrenia was treated with a wide range of antipsychotic medications since diagnosis. She had experienced no clinically significant symptomatic relief until she commenced treatment on clozapine. Her psychotic symptoms, self care, and general sense of well-being improved significantly. After 6 years of successful treatment, she developed leukopenia and clozapine was discontinued. The following issues will be discussed in the article: rechallenge with clozapine following leukopenia during previous therapy and the choice of and haematological monitoring needs with other antipsychotic medications after clozapineinduced blood dyscrasia.

AB - A patient with a 28-year history of schizophrenia was treated with a wide range of antipsychotic medications since diagnosis. She had experienced no clinically significant symptomatic relief until she commenced treatment on clozapine. Her psychotic symptoms, self care, and general sense of well-being improved significantly. After 6 years of successful treatment, she developed leukopenia and clozapine was discontinued. The following issues will be discussed in the article: rechallenge with clozapine following leukopenia during previous therapy and the choice of and haematological monitoring needs with other antipsychotic medications after clozapineinduced blood dyscrasia.

KW - Agranulocytosis

KW - Blood dyscrasia

KW - Clozapine

KW - Leukopenia

KW - Neutropenia

KW - Rechallenge with clozapine

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Clozapine-induced late leukopenia

Abstract

Keywords

ASJC Scopus subject areas

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