Clozapine for treatment-resistant agitation in dementia

Hochang B. Lee; Jennifer A. Hanner; Jessica L. Yokley; Brian Appleby; Lisa Hurowitz; Constantine G. Lyketsos

doi:10.1177/0891988707303335

Clozapine for treatment-resistant agitation in dementia

Hochang B. Lee, Jennifer A. Hanner, Jessica L. Yokley, Brian Appleby, Lisa Hurowitz, Constantine G. Lyketsos

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Few studies have examined the potential role of clozapine in treatment of agitation in dementia patients who have previously failed to respond to standard pharmacotherapy. We conducted a systematic chart review of all elderly patients admitted to our inpatient unit between 2001 and 2004. Of them, 16 dementia patients were treated with clozapine for treatment-resistant agitation, and their charts were blindly rated by 3 clinicians on the Clinical Global Impression (CGI) Scale, Brief Agitation Rating Scale (BARS), and the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF). Overall, clozapine therapy seemed beneficial in treatment-resistant agitation in dementia patients.

Original language	English (US)
Pages (from-to)	178-182
Number of pages	5
Journal	Journal of Geriatric Psychiatry and Neurology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1177/0891988707303335
State	Published - Sep 2007

Keywords

Agitation
Clozapine
Dementia
Treatment

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.1177/0891988707303335

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Clozapine for treatment-resistant agitation in dementia

Abstract

Keywords

ASJC Scopus subject areas

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