Abstract
Few studies have examined the potential role of clozapine in treatment of agitation in dementia patients who have previously failed to respond to standard pharmacotherapy. We conducted a systematic chart review of all elderly patients admitted to our inpatient unit between 2001 and 2004. Of them, 16 dementia patients were treated with clozapine for treatment-resistant agitation, and their charts were blindly rated by 3 clinicians on the Clinical Global Impression (CGI) Scale, Brief Agitation Rating Scale (BARS), and the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF). Overall, clozapine therapy seemed beneficial in treatment-resistant agitation in dementia patients.
Original language | English (US) |
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Pages (from-to) | 178-182 |
Number of pages | 5 |
Journal | Journal of Geriatric Psychiatry and Neurology |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2007 |
Keywords
- Agitation
- Clozapine
- Dementia
- Treatment
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Psychiatry and Mental health