Clozapine for treatment-resistant agitation in dementia

Hochang B. Lee, Jennifer A. Hanner, Jessica L. Yokley, Brian Appleby, Lisa Hurowitz, Constantine G. Lyketsos

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Few studies have examined the potential role of clozapine in treatment of agitation in dementia patients who have previously failed to respond to standard pharmacotherapy. We conducted a systematic chart review of all elderly patients admitted to our inpatient unit between 2001 and 2004. Of them, 16 dementia patients were treated with clozapine for treatment-resistant agitation, and their charts were blindly rated by 3 clinicians on the Clinical Global Impression (CGI) Scale, Brief Agitation Rating Scale (BARS), and the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF). Overall, clozapine therapy seemed beneficial in treatment-resistant agitation in dementia patients.

Original languageEnglish (US)
Pages (from-to)178-182
Number of pages5
JournalJournal of Geriatric Psychiatry and Neurology
Issue number3
StatePublished - Sep 2007


  • Agitation
  • Clozapine
  • Dementia
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Clozapine for treatment-resistant agitation in dementia'. Together they form a unique fingerprint.

Cite this