Clonidine withdrawal complicated by amitriptyline therapy

J. L. Stiff, D. B. Harris

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Withdrawal from clonidine characterized by rebound hypertension and tachycardia is a recognized, but infrequent, complication of therapy with this drug. The withdrawal syndrome may be exacerbated by other drug therapy, particularly beta adrenergic receptor blockers. We recently encountered a patient who had a lengthy period of rebound hypertension, tachycardia, and anxiety after sudden cessation of clonidine and amitriptyline therapy. A case report is presented.

Original languageEnglish (US)
Pages (from-to)73-74
Number of pages2
Issue number1
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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